Words similar to apses
Example sentences for: apses
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The KilA-N, APSES and TEN-terminal domains lack the equivalent residues of the specific active-site extension of the LAGLIDADG nucleases, suggesting that the former domains do not possess nuclease activity.
The multiple alignment shows that the Bro-N domains contain two highly conserved aromatic or hydrophobic residues at the end of the second and fourth conserved strands, a pattern that is reminiscent of similarly conserved residues in the KilA-N and APSES domains (Figure 3).
For example, a search initiated with the KilA-N domain of Pseudomonas phage D3 Orf11 (gi:9635595) recovered the APSES domain of Saccharomyces MBP1p with an E-value of 0.05 in iteration 3. Reciprocal searches with the profiles of APSES domains, similarly recovered the KilA-N domain with borderline E-values.
The sequence relationship with the APSES domain, taken together with the evidence of DNA binding by the D6R/N1R protein [ 12], suggests that the KilA-N domain is a previously undetected DNA-binding domain that is prevalent in the viral world.
The APSES domains principally bind specific DNA sequences associated with regulatory regions of numerous genes expressed in the G1 to S transition of the cell cycle in yeast [ 25, 26].