Words similar to apoptogenic

Example sentences for: apoptogenic

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It is a mixture of eight stereoisomers in equal amounts designated "dl" or all-rac tocopherol and does have antioxidant properties [ 4 ] . Thus, different forms of vitamin E can have different antioxidant properties as well as differences in their absorption, distribution, and metabolism [ 4 ] . There are also reports that some forms of vitamin E have activity against cancer cells in vitro [ 3 5 ] . For example, tocotrienol and vitamin E succinate are reported to have antiproliferative activity in human cancer cells whereas some forms of vitamin E are reported to induce apoptosis in cancer cell types but not in normal cell types [ 3 ] . Specifically, these apoptogenic forms include RRR-α-tocopheryl succinate and RRR-δ-tocopherol while the α, β, and γ tocopherol and acetate derivatives of tocopherol were not apoptogenic [ 3 ] . There are few reports on the use of vitamin E for treating tumorous cancers in vivo but the results are inconsistent [ 4 5 6 7 8 9 10 ] . It is therefore essential that the form of vitamin E used in any research study as well as the dosage and the mode of administration be defined.
We used CPT, an inhibitor of topoisomerase I, that is a well defined apoptogenic agent belonging to a promising class of antineoplastic drugs [ 23 ] . In contrast to more physiological stimuli (i.e, oxidative stress) induction of apoptosis by CPT is less complex and thus is a better model for study of MP-release phenomenon.