Words similar to apcs

Example sentences for: apcs

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, genetically identical, except for the gene of interest), carrying the same 129 region on Chromosome 1, but expressing Apcs . Amazingly, no difference was found between the two strains regarding the production of autoantibodies, clearly eliminating Apcs deficiency as a mechanism for this autoimmune process.
Skin antigen-presenting cells (Langerhans cells) appear to play an important role in the initiating events that lead to the cytokine cascade that results in keratinocyte proliferation and development of psoriatic lesions [ 16 17 18 ] . Effective therapeutic approaches to psoriasis treatment, such as psoralen UV-A therapy (PUVA), which result in depletion of APCs in the skin [ 19 20 ] , and UV-B [ 21 ] , lead to one of the most sustained improvement in psoriasis.
This group has published that Apcs −/− mice on a (129 × B6) genetic background develop a lupus-like disease, even after repeated backcrosses to B6 (Bickerstaff et al.
The present study was performed to examine the effect of propylthiouracil treatment of patients with plaque psoriasis on CD1a expression in their psoriatic lesions in order to determine whether this form of therapy resulted in depletion of APCs from affected skin, that could account for the therapeutic benefit of PTU in this disorder.
Apcs deficiency was however associated with markedly increased renal damage, suggesting that this gene may be involved in preventing pathological consequences of autoantibody production.