Words similar to apcs
Example sentences for: apcs
How can you use “apcs” in a sentence? Here are some example sentences to help you improve your vocabulary:
In a critical experiment, Botto and colleagues compared the autoimmune phenotypes of Apcs −/− mice to congenic mice (i.e.
SLC/CCL21, a CC chemokine expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts naive T cells and DCs [ 1 2 3 4 5 6 7 8 ] . Because DCs are potent APCs that function as principal activators of T cells, the capacity to facilitate the co-localization of both DC and T cells may reverse tumor-mediated immune suppression and orchestrate effective cell-mediated immune responses [ 9 10 25 26 27 ] . In addition to its immunotherapeutic potential, SLC/CCL21 has been found to have potent angiostatic effects [ 28 ] , thus adding further support for its use in cancer therapy.
Consequently, heteroclitic peptide analogs are predicted to be more immunogenic than their native counterparts because of more stable binding at the surface of antigen-presenting cells (APCs).
, genetically identical, except for the gene of interest), carrying the same 129 region on Chromosome 1, but expressing Apcs . Amazingly, no difference was found between the two strains regarding the production of autoantibodies, clearly eliminating Apcs deficiency as a mechanism for this autoimmune process.
We hypothesized that high antigen densities on APCs resulting from vaccination with heteroclitic peptide may paradoxically drive T cells of predominantly low RE, which are not efficiently activated by the endogenous expression levels of native peptides on tumor cells.
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