Example sentences for: apc

How can you use “apc” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • They showed APC1's affinity for Ca 2+and the potential for a Ca 2+-dependent conformational change.

  • Even though Wnt-1 has not been directly implicated in human cancers, many components of the Wnt signaling pathway (such as β-catenin, APC, c-myc, and cyclin D 1) are involved in human tumors including breast cancer [reviewed in ref.

  • The other four genes ( BRCA1 , APC , CDH1 , and TIMP3 ) did not show a consistent pattern of correlation between methylation and loss of gene expression (Table 1).

  • We found that methylation of HIC1 , APC , and BRACA1 genes was more common in AC while CDH1 promoter methylation was seen only in SCC.

  • The APC is a large protein complex that ubiquinates mitotic cyclins and other regulatory proteins that are destined for timely proteolysis by proteasomes [ 10 20 ] . Proteasomes are multicatalytic 26S proteases consisting of a 20S central core catalytic subunit bordered by two 19S components [ 32 33 ] which hydrolyze C-terminal peptide bonds to acidic, basic, and hydrophobic amino-acid residues [ 20 34 ] . Proteasomes proteolyze securins which inhibit separase activity.


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