Words similar to apc
Example sentences for: apc
How can you use “apc” in a sentence? Here are some example sentences to help you improve your vocabulary:
We found that methylation of HIC1 , APC , and BRACA1 genes was more common in AC while CDH1 promoter methylation was seen only in SCC.
This developmentally important pathway contains several proteins, including APC, Frizzled, Axin and GSK3, which act in concert to promote the proteosomal degradation of β-catenin [ 13 14 ] . When APC is rendered inactive by mutation, β-catenin levels rise and the protein moves into the nucleus where it acts with Tcf/Lef cofactors to regulate transcription of c-myc , cyclin D and other oncogenes [ 15 ] .
Allophycocyanin (APC)-conjugated CD14 (Becton, Dickinson and Co, San Jose, CA, USA) was added, and the cells were incubated for a further 20 min in the dark.
The APC is a large protein complex that ubiquinates mitotic cyclins and other regulatory proteins that are destined for timely proteolysis by proteasomes [ 10 20 ] . Proteasomes are multicatalytic 26S proteases consisting of a 20S central core catalytic subunit bordered by two 19S components [ 32 33 ] which hydrolyze C-terminal peptide bonds to acidic, basic, and hydrophobic amino-acid residues [ 20 34 ] . Proteasomes proteolyze securins which inhibit separase activity.
The rational for this approach was the markedly increased incidence of medulloblastomas seen in PTCH heterozygotes deficient for p53, and the enhanced intestinal adenoma phenotype of p53 null, APC heterozygous Min mice [ 12 32 ] . We did not observe any significant phenotypic changes in the CNS of β-catenin transgenic animals heterozygous or homozygous for disruption of the p53 locus.
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