Words similar to antitumor
Example sentences for: antitumor
How can you use “antitumor” in a sentence? Here are some example sentences to help you improve your vocabulary:
d-Limonene, which comprises > 90% of citrus peel oil, has demonstrated chemopreventive activity against a variety of chemically induced rodent cancers [ 17 18 19 20 21 22 ] . Several mechanisms of action may account for the antitumor activities of d-limonene [ 23 24 25 ] . Among citrus bioflavonoids, hesperidin and naringin have been tested as potential chemopreventive agents [ 26 27 ] . In our previous studies, we showed that citrus peel use [ 28 ] and consumption of hot (strong) black tea [ 29 ] were each independently associated with reduced risk of skin SCC.
Clearly, more research is needed on the antitumor effects of sE but caution is advised that sE may also have side-effects in the heart.
The observed antitumor activity of this sE dietary supplementation was an unexpected experimental result as sE was not previously reported to have antitumor activity although vitamin E may give modest protection against the risk of breast cancer [ 5 ] . Based on the observed antitumor activity of high dose sE in the diet, it became important to investigate if the sE supplement, when fed at such a high dose, was associated with the modification of the fatty acid composition of mitochondrial and microsomal membranes and if the sE was acting as an antioxidant or possibly a prooxidant in tumor and in host tissues.
Because of the high catalytic efficiency and broad substrate specificity, β-lactamases have been extensively used in the ADEPT approach to activate prodrugs of vinca alkaloids [ 27 ] , nitrogen mustard [ 28 29 30 31 32 ] , doxorubicin [ 33 34 35 36 ] and others [ 37 ] . To take advantage of the potent antitumor activity of the CC-1065 class of compounds and the ADEPT approach, we have synthesized β-lactam prodrugs.
In one report, ALDH1A1 protein was not detected by Western blot, but enzyme activity was detected using flow cytometry and a fluorescent aldehyde substrate [ 5 ] . In a second study, ALDH1A1 protein was detected using an ELISA assay and activity was detected using aldophosphamide as substrate [ 31 ] . In these two studies, designed to look at the relationship of ALDH1A1 activity to antitumor drug resistance, the levels of ALDH1A1 were low in HL-60 compared to other cell types, corresponding to the sensitivity of HL-60 cells to oxazaphosphorines.
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