Words similar to antisense-mediated

Example sentences for: antisense-mediated

How can you use “antisense-mediated” in a sentence? Here are some example sentences to help you improve your vocabulary:

Inhibiting the expression of eIF4E by expressing antisense RNA reverses ras-mediated transformation of cultured cells as indicated by decreased efficiency of growth in soft agar and tumor formation in nude mice [ 20 ] . Similarly, antisense-mediated reduction of eIF4E in breast cancer cells inhibits both their tumorigenic and angiogenic properties [ 21 ] . On the other hand, overexpression of 4EBP reverses transformation mediated by v-src [ 18 ] .
This is consistent with previous observations that M6P/IGF2R knockout mice displayed generalized increased growth and cardiomygaly (resulting from cardiac myocyte hyperplasia) [ 34 ] , and that antisense-mediated reduction of M6P/IGF2R expression enhances tumorigenicity in JEG-3 cells [ 43 ] . Thus, loss or mutation of M6P/IGF2R may contribute to development and progression of tumors via different pathways: by increasing the mitogenic activity of IGF-II and decreasing the apoptotic signaling of TGF-β and lysosomal proteases.
(This could be explained in several ways: as an example of antisense-mediated translational control, as two separate proteins on opposite strands, perhaps expressed in different cell types, or simply erroneous data.)