Words similar to antiretroviral-experienced
Example sentences for: antiretroviral-experienced
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No significant differences were observed between the APV600/RTV and APV1200 treatment arms with respect to mean AAUCMB in HIV-1 RNA for the antiretroviral-experienced subgroup (-1.
The proportion of antiretroviral-naïve patients who achieved HIV-1 RNA <50 copies/mL was 47% (14/30) in the APV600/RTV arm and 20% (2/10) in the APV1200 arm ( P = 0.141), whereas the proportion of antiretroviral-experienced patients who achieved HIV-1 RNA <50 copies/mL was 34% (43/128) in the APV600/RTV arm and 21% (9/43) in the APV1200 arm ( P = 0.119) (ITT:M = F analysis).
The greater magnitude of virologic suppression in the study population as a whole with the APV600/RTV regimen was expected in view of the results of earlier clinical pharmacokinetic studies showing a >6-fold higher C min level with APV600/RTV BID compared with the APV1200 BID regimen [ 16 ] . Higher C min values achieved with RTV-boosting may be critical in treating antiretroviral-experienced patients, particularly those with HIV isolates having increased IC 50 values.
A total of 211 patients enrolled; they were predominantly male (87%), ethnically diverse (48% Caucasian, 37% African American, 14% Hispanic), and had a mean age of 42 years, median baseline HIV-1 RNA level of 4.33 log 10 copies/mL, and median baseline CD4+ cell count of 257 cells/mm 3. Most of the study population was antiretroviral-experienced (81%).
In contrast, the proportions in antiretroviral-experienced patients were similar in the treatment arms in both analyses (ITT: M = F analysis: 42% [54/128] vs 40% [17/43], P = 0.859; ITT: observed analysis: 58% [54/93] vs 53% [17/32], P = 0.682).
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