Words similar to antipsychotic
Example sentences for: antipsychotic
How can you use “antipsychotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Antipsychotic medication use was also consistently found to be a predictor of having an increased risk of disability, regardless of how dependence was measured.
Clozapine is a widely used atypical neuroleptic with affinity for multiple receptors, including dopamine, serotonin, alpha adrenergic, muscarinic and histaminergic receptors [ 1 2 ] . Although clozapine is effective in the treatment of schizophrenia refractory to traditional antipsychotic medication, it also has a number of significant side effects ranging from the potentially fatal but rare agranulocytosis to weight gain, constipation, seizures and urinary incontinence [ 3 ] . Urinary problems have been reported in the clinical literature with incontinence present in up to 44% of patients [ 4 ] and enuresis in 27% of patients [ 5 ] . Since clozapine has potent anti-muscarinic and anti-alpha adrenergic effects [ 2 ] , it has been proposed that peripheral effects on the lower urinary tract might be responsible for the micturition disturbances [ 6 ] . Incontinence has also been reported following therapy with other atypical neuroleptics such as risperidone [ 7 8 9 ] and recently, olanzapine [ 10 ] .
A one-point difference of the ADAS-cog score was associated with an increase in the adjusted odds for requiring >12 hours supervision per day of 4% (95% CI 3-5) and for dependence level > = 3 of 8% (95% CI 6-9), after adjusting for age, gender and use of antipsychotic medication.
Olanzapine is a newer atypical antipsychotic agent with a pharmacological profile very similar to that of clozapine [ 11 ] . In human brain tissue, olanzapine displays very high affinity for the H1 histamine receptor, high affinity for 5-HT2A and 5-HT2C receptors [ 12 ] . In addition it also shows affinity for D2, muscarinic, and alpha1 receptors, with lower affinity for alpha2, 5-HT1D and 5-HT1A receptors (Table 1 [ 12 ] ).
Atypical neuroleptics are useful in treating patients that are refractory to "traditional" antipsychotic medication and produce fewer extrapyramidal side effects.
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