Words similar to antiproliferative
Example sentences for: antiproliferative
How can you use “antiproliferative” in a sentence? Here are some example sentences to help you improve your vocabulary:
Based on its antiprogesterone activity, RU486 has been evaluated as a useful anticancer agent in organs sensitive to this hormone [ 4 ] . Although evidence was not conclusive in these studies, RU486 demonstrated a benefit to humans suffering from meningioma, breast cancer and uterine leiomyomata [ 4 ] . Several in vitro studies also demonstrated that RU486 induced antiproliferative effects against murine mammary tumors [ 5 ] as well as cultured human endometrial stromal and epithelial cells [ 6 7 ] .
It is well established that, besides the MHCII molecules, IFNg can induce susceptible tumors to upregulate the expression of MHC class I antigens [ 43 ] , tumor associated antigens [ 44 ] , costimulatory molecules [ 45 ] , and heat shock proteins [ 46 ] . In addition, IFNg may have antimetabolic and antiproliferative influence on certain types of tumor cells [ 47 ] . It has also been suggested that IFNg may cause responding tumor cells to secrete angiogenesis inhibitors [ 48 ] . As it is not known which of those IFNg effects are missing or restored by PMA in LS1034 cells, a thorough evaluation of the possible clinical implications of our in vitro findings is quite difficult.
The antiproliferative effects of RA have been recognized for many years.
It is a mixture of eight stereoisomers in equal amounts designated "dl" or all-rac tocopherol and does have antioxidant properties [ 4 ] . Thus, different forms of vitamin E can have different antioxidant properties as well as differences in their absorption, distribution, and metabolism [ 4 ] . There are also reports that some forms of vitamin E have activity against cancer cells in vitro [ 3 5 ] . For example, tocotrienol and vitamin E succinate are reported to have antiproliferative activity in human cancer cells whereas some forms of vitamin E are reported to induce apoptosis in cancer cell types but not in normal cell types [ 3 ] . Specifically, these apoptogenic forms include RRR-α-tocopheryl succinate and RRR-δ-tocopherol while the α, β, and γ tocopherol and acetate derivatives of tocopherol were not apoptogenic [ 3 ] . There are few reports on the use of vitamin E for treating tumorous cancers in vivo but the results are inconsistent [ 4 5 6 7 8 9 10 ] . It is therefore essential that the form of vitamin E used in any research study as well as the dosage and the mode of administration be defined.
The antiproliferative effects of RA have been attributed to its inhibition of AP-1 transcriptional activity [ 13 ] . While the S77A RARα mutant has been shown to inhibit transactivation of RA response elements [ 7 ] , its effects on AP-1 activity have not been characterized.
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