Words similar to antiproliferative
Example sentences for: antiproliferative
How can you use “antiproliferative” in a sentence? Here are some example sentences to help you improve your vocabulary:
Based on its antiprogesterone activity, RU486 has been evaluated as a useful anticancer agent in organs sensitive to this hormone [ 4 ] . Although evidence was not conclusive in these studies, RU486 demonstrated a benefit to humans suffering from meningioma, breast cancer and uterine leiomyomata [ 4 ] . Several in vitro studies also demonstrated that RU486 induced antiproliferative effects against murine mammary tumors [ 5 ] as well as cultured human endometrial stromal and epithelial cells [ 6 7 ] .
The antiproliferative effects of RA have been recognized for many years.
It is well established that, besides the MHCII molecules, IFNg can induce susceptible tumors to upregulate the expression of MHC class I antigens [ 43 ] , tumor associated antigens [ 44 ] , costimulatory molecules [ 45 ] , and heat shock proteins [ 46 ] . In addition, IFNg may have antimetabolic and antiproliferative influence on certain types of tumor cells [ 47 ] . It has also been suggested that IFNg may cause responding tumor cells to secrete angiogenesis inhibitors [ 48 ] . As it is not known which of those IFNg effects are missing or restored by PMA in LS1034 cells, a thorough evaluation of the possible clinical implications of our in vitro findings is quite difficult.
Laboratory investigations support the capability of citrus peel or its major constituents, d-limonene, and also the ability of tea extract or its constituents, tea polyphenols to reduce not only the incidence and tumor size of chemically-induced tumors at several sites [ 4 8 9 17 18 20 22 ] but also the growth of various tumor cells in culture [ 11 33 ] . Both d-limonene, representative of citrus peel, and tea polyphenols, representative of black tea, are known to impact antiproliferative effects, including apoptosis, on neoplastic cells [ 4 34 35 36 37 ] . Dietary d-limonene has been shown to be effective in the chemoprevention and chemotherapy of cancer.
The drugs have been studied with relation to their effect in Graves' hyperthyroidism which, like psoriasis, is an autoimmune disorder [ 9 10 11 12 ] Antithyroid thioureylenes, of which propylthiouracil, methimazole and carbimazole are used in clinical practice, have known immunomodulatory properties [ 13 14 ] and, in the case of psoriasis, also have antiproliferative effects as demonstrated by their ability to produce a decline in markers of cellular proliferation such as proliferative cell nuclear antigen (PCNA) [ 15 ] .
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