Words similar to antinociceptive
Example sentences for: antinociceptive
How can you use “antinociceptive” in a sentence? Here are some example sentences to help you improve your vocabulary:
Yet, some selective δ ligands have been shown to be ineffective antinociceptive agents when given systemically [ 14 15 16 ] . The reason for this ineffectiveness is not clear.
Phyllanthus urinaria plant was used by Caribs with other plants in a bath against bad luck (called 'piai') [ 66 ] . Pharmacological activities of various compounds in some species of Phyllanthus include analgesic, antiinflammatory, antilipoxigenase, antiallergic, nitrosamina blocker, aldose reductase inhibitor, antiviral, mitochondrial ATPase inhibitor, phosphodiesterase inhibitor and cyclooxigenase inhibitor [ 111 ] . Other activities are hepatoprotective, phosphorilase and tirosine kinase inhibitor, phospholipase A 2 inhibitor and increased the survival of hepatocellular carcinoma harbouring animals [ 54 111 113 112 ] . The compound with hepatoprotective activity is triacontanol [ 114 ] . Several compounds found in Phyllanthus species, like flavonoids (quercetin, rutin), tannins (geraniin, furosin), benzenoids (ethyl gallate, methyl gallate) and phytosterols showed antinociceptive effects in mice or multiple mechanisms of action [ 111 115 ] . The flavonoids also have anti-inflammatory properties [ 38 11 ] . The hydroalcoholic extracts of four Phyllanthus species were 2 - 6 fold more active in causing antinociception than aspirin depending on the route of administration and the pain model used [ 115 ] . Phyllanthus amarus has antioxidant properties, reverses chromosomal alterations induced by genotoxic agents and has anticancer activity [ 112 ] . Active compounds may be flavonoids (quercetin, astragalin), ellagitannins (amarinic acid), hydrolysable tannins (phyllanthisiin D) [ 112 ] . The multiple plant compounds found in Phyllanthus species might help clear up any physiological condition that results in dogs having difficulty following game animals.
However, in another study, butorphanol was reported to be equipotent in its antinociceptive effect to that of morphine [ 32 ] . In our assays, we have observed that butorphanol and morphine are equally efficacious in inhibiting cAMP production, although butorphanol is more potent than morphine in this assay.
Based on these two sets of results, if the analgesic effect of butorphanol is mediated via μ opioid receptors through the inhibitory effect of these receptors on adenylyl cyclase, the equal efficacy of morphine and butorphanol would support an equal antinociceptive effect of these two drugs.
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