Words similar to anti-apoptotic
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Example sentences for: anti-apoptotic
How can you use “anti-apoptotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, activation of the p110-PI 3-kinase/PKB pathway delivers an anti-apoptotic signal to the cell [ 23, 25, 47].
Akt directly phosphorylates and inactivates the pro-apoptotic proteins ASK1, BAD, caspase 9 [ 21 22 23 24 ] . Akt also induces the expression of the anti-apoptotic Bcl-2 and c-FLIP proteins, and suppresses the cell cycle inhibitor p27 KIP [ 25 26 27 28 ] . This later effect is via the phosphorylation and inactivation of the forkhead family of transcription factors AFX, FKHR and FKHR-L1.
Induction of inhibitor of apoptosis proteins (IAP) is one such mechanism [ 41 42 43 ] . In vascular smooth muscle cells, surface expression of Fas [ 44 ] and molecules involved in signaling the apoptotic process, such as caspase-8 and caspase-3, appear to be regulated and provide another level of cellular control of apoptosis [ 45 ] . However, the potential anti-apoptotic mechanisms present early in the course were ineffective by day 21, when caspase-8 activation was evident.
Mcl-1 is an anti-apoptotic member of the Bcl-2 family whose expression is correlated with decreased apoptosis and increased survival in human neutrophils [ 15 16 ] . Western blot analysis showed that neutrophils from control animals did not express Mcl-1 protein (Fig.
Another important class of genes that might contribute to the efficacy of flavopiridol would include anti-apoptotic genes with rapid mRNA turnover (Figure 4b).
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