Words similar to anti-apoptotic
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- anti-apoptotically
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Example sentences for: anti-apoptotic
How can you use “anti-apoptotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
It was suggested that down-regulation of PS1 by wildtype p53 and also p21 WAF-1may be independent mechanisms leading to apoptosis and tumor suppression [ 24 ] . Our data correlating PS1 with IL-8-tumor related tissue also suggest a potential anti-apoptotic role for PS1 in tumorigenesis.
This activation of the p110-PI 3-kinase/PKB pathway, and inhibition of GSK3, delivers a strong anti-apoptotic signal to the cell [ 23, 24, 25].
Three members of the IAP family ( c-IAP1, c-IAP2, NAIP ) had very short mRNA half-lives and encode anti-apoptotic proteins that act by directly binding to caspases 3, 7, and 9 [ 27].
When examining the physiological role of 5-HT in other cell types, in regards to apoptosis and cellular responses to stress, 5-HT is generally anti-apoptotic [ 30 31 32 ] . In particular, in neuronal cells the 5-HT 1A receptor is upregulated under conditions of cellular stress and is anti-apoptotic [ 33 34 ] . The anti-apoptotic effects of 5-HT maybe due to scavenging of reactive oxygen species [ 35 ] as well as stimulation of the ERK pathway which results in inhibition of a caspase-3-like enzyme [ 32 ] . There are no currently published studies examining the role of 5-HT as an anti-apoptotic factor in vascular smooth muscle cells.
In accord with these results, flavopiridol treatment was recently shown to downregulate two of these anti-apoptotic proteins, MCL1 and Bag-1, and induce apoptosis in B-CLL cells treated with flavopiridol [ 29].
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