Words similar to androstanol

Example sentences for: androstanol

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To examine the effects of RXR ligands on CAR transactivation in a more functional context, the rexinoid LG1069 was combined with the CAR inverse agonist androstanol and the agonist TCPOBOP in a series of transient transfection studies using different response elements.
In more detailed dose response studies, 100 nM LG1069 decreased the inhibitory effect of androstanol by as much as 70% and had an even stronger effect on TCPOBOP activation (Fig.
Finally, expression of the endogenous CYP2B6 gene in CAR expressing HepG2 cells is modestly inhibited by LG1069 alone, androstanol alone and the combination of both.
The rexinoid alone has no effect on transactivation of the βRARE, but strongly inhibits responses to both the agonist TCPOBOP and the inverse agonist androstanol.
These results show that the negative effects of rexinoids on TCPOBOP and androstanol signaling observed with the DR-5 site from the RARβ promoter are not observed with the DR-4 and ER-6 sites from the CYP promoters.