Words similar to analogues

Example sentences for: analogues

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Leptin analogues (chemical cousins) are also being developed.
CC-1065 (Figure 1) is among the most potent antitumor agents discovered [ 9 10 11 12 13 ] . It binds to double-stranded B-DNA within the minor groove with a sequence preference for 5'-d(A/GNTTA)-3' and 5'-d(AAAAA)-3', and alkylates the N3 position of the 3'-adenine with its left-hand CPI segment [ 14 15 ] . CC-1065 also inhibits gene transcription by interfering with binding of the TATA box-binding protein to its target DNA [ 16 ] . Despite its high potency and broad spectrum of antitumor activity, CC-1065 cannot be used in humans because it causes delayed death in experimental animals [ 17 ] . To pursue compounds possessing the potent antitumor activity but devoid of the toxic side effects of the parent compound, many CC-1065 analogues have been synthesized [ 18 19 20 21 22 23 24 25 26 ] .
We set to identify the pharmacophores responsible for each of these pharmacological activities so as to provide guidelines for the synthesis of new and possibly more potent analogues.
In particular, analogues of Asp-85, Asp96, Arg-82, and Lys-216 of bR are present in pR.
Conspicuously absent are analogues for Glu-194 and Glu-204 of bR.