Example sentences for: analogues

How can you use “analogues” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • CC-1065 (Figure 1) is among the most potent antitumor agents discovered [ 9 10 11 12 13 ] . It binds to double-stranded B-DNA within the minor groove with a sequence preference for 5'-d(A/GNTTA)-3' and 5'-d(AAAAA)-3', and alkylates the N3 position of the 3'-adenine with its left-hand CPI segment [ 14 15 ] . CC-1065 also inhibits gene transcription by interfering with binding of the TATA box-binding protein to its target DNA [ 16 ] . Despite its high potency and broad spectrum of antitumor activity, CC-1065 cannot be used in humans because it causes delayed death in experimental animals [ 17 ] . To pursue compounds possessing the potent antitumor activity but devoid of the toxic side effects of the parent compound, many CC-1065 analogues have been synthesized [ 18 19 20 21 22 23 24 25 26 ] .

  • Thus, aromatic hydroxylation of such compounds at the ortho-position would form a catechol ring (Table 3, #12) and produce metabolites that are structural analogues to dopamine.

  • Moreover, Slang and Its Analogues is attributed to John S. Farmer and W. E. “Hurley,” the latter's name being, properly, Henley.

  • Conspicuously absent are analogues for Glu-194 and Glu-204 of bR.

  • Since CPT analogues become one of the most promising new classes of antineoplastic agents introduced into the clinic in recent years [ 19 ] , activity of camptothecin on endothelial cells may be of great interest.


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