Words similar to analogues
Example sentences for: analogues
How can you use “analogues” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, the variants were no longer responsive to theophylline, nor were they responsive to a variety of other analogues, including caffeine, 1-methylxanthine, 7-methylxanthine, 1,3-dimethyl urilic acid, hypoxanthine, xanthine, and theobromine (Figure 6b).
[ 70 72 ] For the same reason, mefloquine users should avoid other quinine analogues, such as fluoroquinolone antibiotics.
CC-1065 (Figure 1) is among the most potent antitumor agents discovered [ 9 10 11 12 13 ] . It binds to double-stranded B-DNA within the minor groove with a sequence preference for 5'-d(A/GNTTA)-3' and 5'-d(AAAAA)-3', and alkylates the N3 position of the 3'-adenine with its left-hand CPI segment [ 14 15 ] . CC-1065 also inhibits gene transcription by interfering with binding of the TATA box-binding protein to its target DNA [ 16 ] . Despite its high potency and broad spectrum of antitumor activity, CC-1065 cannot be used in humans because it causes delayed death in experimental animals [ 17 ] . To pursue compounds possessing the potent antitumor activity but devoid of the toxic side effects of the parent compound, many CC-1065 analogues have been synthesized [ 18 19 20 21 22 23 24 25 26 ] .
We set to identify the pharmacophores responsible for each of these pharmacological activities so as to provide guidelines for the synthesis of new and possibly more potent analogues.
PPARs are nuclear hormone receptors that are activated by micromolar concentrations of various FAs and FA analogues, such as fibrates and thiazolidinediones [ 29 ] . This subfamily can be divided into three isotypes, designated PPARα, PPARδ and PPARγ, each with tissue-specific expression.
Loading...