Words similar to ampa

Example sentences for: ampa

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It is interesting to note, however, that in newborn mice a brief local application of 2 mM domoic acid to the exposed cortical surface led to a massive degeneration of AMPA/KA GluR receptor positive Cajal-Retzius neurons [ 44 ] , severe impairment of cortical neuronal migration in vivo and malformation of the domoic acid-treated neocortex [ 44 ] . Thus, because 1 mM domoic acid was clearly toxic to cerebellar granule neurons both in vitro (our current study) and in vivo [ 44 ] , we selected 1 mM domoic acid for the experiments with rat neonatal microglia reported herein.
It has been shown that HIV-infected brain has a decrease of mRNA and protein of the GluR-A flop subtype of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) glutamate receptor in cerebellar Purkinje cells.
The ionotropic AMPA glutamate receptor GluR4 subunit has been shown to be expressed by activated rat adult microglia
Our results clearly confirmed that GluR4 was present in the rat neonatal microglia used in our in vitro studies with domoic acid, demonstrating that the protocol used in our laboratory to isolate microglia did not appear to affect the presence of the AMPA glutamate receptor GluR4 subunits and their colocalization with the CD 11 b/c integrin.
However, the molecular basis for this activity-induced change in AMPA receptors remains unknown.