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Example sentences for: alzheimer
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LHR immunoreactivity in porcine fallopian tubes was confined to the epithelium and smooth muscle cells, and in vitro LH treatment caused relaxation of the oviduct [ 35 ] . Also, LHR stimulation plays a role in the induction and maintenance of myometrial quiescence [ 36 37 38 ] . Since smooth muscles belong among important compartments of the pelvic floor, high LH levels after menopause might be involved in the increased incidence of pelvic floor disorders, a common condition in postmenopausal women [ 39 ] . Since the brain was reported to express functional LHR [ 29 30 ] , there is also a possibility that high LH levels in aging individuals may in some way participate in the development and progression of neurodegenerative process of several degenerative neurological diseases, including Alzheimer's disease.
Cognitive training has demonstrable effects on performance, on views of self, and on brain function—but the results are very specific to the skills that are trained, and it is as yet entirely unknown whether there is any effect on when or whether an individual develops Alzheimer disease.
An accumulation of 4-HNE-conjugated protein has been detected in lesions of aging-related diseases, including Parkinson's disease [ 53 ] and Alzheimer's disease [ 54 ] . It also accumulates in the affected neuronal tissues of experimental animals experiencing brain ischemia [ 55 56 ] and traumatic spinal cord injury [ 57 ] . 4-HNE can impair synaptosomal membrane proteins, glutamate transport and importantly, mitochondrial functions [ 58 59 ] . Evidence indicates that 4-HNE increases neuronal susceptibility to oxidative stress [ 60 ] and serves as a mediator of oxidative stress that leads to neuronal apoptosis [ 61 ] . As indicated in the Introduction, 4-HNE has been implicated in some ocular pathological conditions [ 19 20 ] .
In an age when Ronald Reagan has slipped into the haze of Alzheimer's disease, when Susan Faludi writes movingly of males clinging to stereotypical notions of machismo as they're laid off their factory jobs and symbolically robbed of potency, it can put a lump in your throat to watch Schickel building--like the hero in Field of Dreams --a shrine to the Dad whom so many elements of the culture have come to undervalue.
Alzheimer's Disease is a heritable condition with a well described visual orienting deficit and where associations have been found in unaffected relatives between visual orienting and the apoe gene [ 28 ] . In order to keep the ANT simple the peripheral orienting cues are 100% valid.
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