Words similar to alzheimer
Example sentences for: alzheimer
How can you use “alzheimer” in a sentence? Here are some example sentences to help you improve your vocabulary:
All patients enrolled in these trials were diagnosed with Alzheimer's disease according to NINCDS-ADRDA classification [ 15 ] . The patients had a mild-to-moderate disease (MMSE scores 10-24) with a history of cognitive decline, gradual onset, and progressive disease over a period of at least six months.
Amyloid deposits are composed of the amyloid-β peptide (Aβ), a 4-kDa peptide released during “amyloidogenic” proteolytic processing of the Alzheimer Aβ precursor protein (APP) [2].
These results raise the possibility that the apparent beneficial effect of statins in the prevention of Alzheimer disease could be, at least in part, mediated by isoprenoid modulation of APP metabolism.
An accumulation of 4-HNE-conjugated protein has been detected in lesions of aging-related diseases, including Parkinson's disease [ 53 ] and Alzheimer's disease [ 54 ] . It also accumulates in the affected neuronal tissues of experimental animals experiencing brain ischemia [ 55 56 ] and traumatic spinal cord injury [ 57 ] . 4-HNE can impair synaptosomal membrane proteins, glutamate transport and importantly, mitochondrial functions [ 58 59 ] . Evidence indicates that 4-HNE increases neuronal susceptibility to oxidative stress [ 60 ] and serves as a mediator of oxidative stress that leads to neuronal apoptosis [ 61 ] . As indicated in the Introduction, 4-HNE has been implicated in some ocular pathological conditions [ 19 20 ] .
Taken together, the evidence is very suggestive that having greater cognitive reserve is related to a reduced risk of Alzheimer disease.
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