Example sentences for: allosteric

How can you use “allosteric” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • As intersubunit signaling between TrpEb_2 and TrpEa is either lacking or involves different contacts, one might expect the important catalytic residues, but not the allosteric residues, to be conserved in comparison of TrpEb_2 with TrpEb_1.

  • This comparison is shown in Figure 5. Likewise, in those TrpEa proteins that lack a TrpEb_1 partner, instead being forced to function in concert with TrpEb_2, one might expect retention of catalytic residues but loss of allosteric residues.

  • While we cannot rule out possible allosteric interactions between the peptides, the data suggests that the HSPLs were able to dissect the ligand-binding region of TNFR2 into several structural and/or functional hotspots.

  • In addition to the binding sites for natural or endogenous agonists (orthosteric sites), many GPCRs have also been found to have allosteric sites [ 35 ] . These sites can bind natural ligands, as in the case of Zn ions and heparin for the dopamine and neurokinin receptors, respectively, or bind synthetic drugs such gallamine, in the case of the muscarinic receptors [ 35 ] . Binding of small molecules to these allosteric sites can modulate activity of a receptor without directly mimicking or competing out the interaction of ligands to the orthosteric sites.

  • Finally, catalytically inactive versions of the CYTH domain are found fused to the nucleotide kinase domain in uridine kinase homologs and may serve as an allosteric nucleotide-binding site in these enzymes (Fig.


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