Example sentences for: allosteric

How can you use “allosteric” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In addition to the binding sites for natural or endogenous agonists (orthosteric sites), many GPCRs have also been found to have allosteric sites [ 35 ] . These sites can bind natural ligands, as in the case of Zn ions and heparin for the dopamine and neurokinin receptors, respectively, or bind synthetic drugs such gallamine, in the case of the muscarinic receptors [ 35 ] . Binding of small molecules to these allosteric sites can modulate activity of a receptor without directly mimicking or competing out the interaction of ligands to the orthosteric sites.

  • Competing allosteric conformations are mediated by alternative salt bridges between K167 of TrpEb_1 and D305 of TrpEb_1 on the one hand, or between K167 of TrpEb_1 and D56 of TrpEa, on the other.

  • , to serve as a membrane-localization tag) [ 13 14 ] . In other proteins, the binding of PH domains to phospholipids appears to be important for allosteric or other types of regulation [ 15 16 ] .

  • In response to receptor activation, Syk becomes non-covalently associated with the BCR through tandem SH2 domains located in the amino terminal half of the protein [ 44 ] . Following engagement of the BCR, phosphorylation of specific tyrosine residues in immunoreceptor tyrosine-based activation motifs (ITAMs) found within the cytoplasmic tails of CD79a and CD79b provides docking sites for Syk localization [ 45 46 47 ] . The ability of phosphorylated ITAM peptides to selectively enhance Syk kinase activity in vitro suggests that recruitment of Syk to the receptor complex may serve to activate the kinase, in part, through allosteric changes in the structure of the Syk protein [ 44 48 49 ] . Upon activation, Syk and the receptor complex become localized in detergent-resistant cholesterol-rich membrane microdomains (lipid rafts), resulting in the segregation of the BCR complex from other membrane components [ 50 ] .

  • This comparison is shown in Figure 5. Likewise, in those TrpEa proteins that lack a TrpEb_1 partner, instead being forced to function in concert with TrpEb_2, one might expect retention of catalytic residues but loss of allosteric residues.


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