Example sentences for: all-trans

How can you use “all-trans” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The crystal structure of RAR-γ-LBD complexed to all-trans RA was used as a template [ 18] and the three residues in the vicinity of the ligand which are not conserved between the two isoforms were modified accordingly: A234, M272, and A397 were changed to S234, I272 and V397 respectively.

  • Exposure to 1 μM all-trans retinal for 96 hours induced differentiation equivalent to exposure to 0.05-0.

  • Agonist 1 and 2 both have a carboxylate group which superimposes with the carboxylate of all-trans RA, and makes stabilizing hydrogen bonds with Arg 274 and 278, and the backbone nitrogen of Ser 289 (Fig.

  • Raner et al [ 34 ] and Chen et al [ 35 ] have described the formation of all-trans retinoic acid from retinal and retinol by members of the CYP1 and CYP3A families.

  • The HL-60 human promyelocytic leukemia cell line responds in culture to sub-micromolar concentrations of retinoic acid ( all-trans and 13-cis ) by undergoing terminal differentiation to a granulocytic cell with the ability to phagocytose and reduce nitroblue tetrazolium [ 28 ] . The response to retinoic acid in HL-60 cells is dependent on the expression of the retinoic acid receptor RAR α [ 29 ] . The use of all-trans retinoic acid in differentiation therapy for patients with acute promyelocytic leukemia has resulted in prolonged, complete remissions when combined with cytotoxic chemotherapy, and may provide complete, long-term remissions as a single agent [ 30 ] .


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