Words similar to all-trans
Example sentences for: all-trans
How can you use “all-trans” in a sentence? Here are some example sentences to help you improve your vocabulary:
The CR-II domain plays an essential role in the ability of TAF II 135 to potentiate ligand-dependent transactivation by the the receptor for all-trans retinoic acid (RAR) in transfected mammalian cells [ 5, 33].
In vitro, purified mouse [ 11 ] , human [ 12 ] , and Xenopus [ 13 ] ALDH1A1 can efficiently oxidize all-trans retinal to all-trans retinoic acid.
Agonist 1 and 2 both have a carboxylate group which superimposes with the carboxylate of all-trans RA, and makes stabilizing hydrogen bonds with Arg 274 and 278, and the backbone nitrogen of Ser 289 (Fig.
The effects of specific RXR ligands on the CAR/RXR heterodimer have not been characterized, although high concentrations of both 9-cis-RA and all-trans retinoic acid have been reported to block PB induction of the CAR targets CYP2B1 and CYP2B2 in primary rat hepatocytes [ 17 ] . In addition, a recent report suggests that both compounds decrease TCPOBOP-dependent CAR transactivation [ 18 ] . In both cases, these effects were primarily attributed to sequestration of limiting amounts of RXR into ligand-dependent homodimers or heterodimers with other receptors.
The HL-60 human promyelocytic leukemia cell line responds in culture to sub-micromolar concentrations of retinoic acid ( all-trans and 13-cis ) by undergoing terminal differentiation to a granulocytic cell with the ability to phagocytose and reduce nitroblue tetrazolium [ 28 ] . The response to retinoic acid in HL-60 cells is dependent on the expression of the retinoic acid receptor RAR α [ 29 ] . The use of all-trans retinoic acid in differentiation therapy for patients with acute promyelocytic leukemia has resulted in prolonged, complete remissions when combined with cytotoxic chemotherapy, and may provide complete, long-term remissions as a single agent [ 30 ] .
Loading...