Words similar to alkylating
Example sentences for: alkylating
How can you use “alkylating” in a sentence? Here are some example sentences to help you improve your vocabulary:
AlkB binds ssDNA and is required for the processing of toxic DNA modifications caused by SN2 alkylating agents such as methylmethanesulfonate (MMS) specifically on ssDNA.
Given the presence of RNA methylases that could modify RNA in a similar way as the alkylating agents the function of the uncharacterized AlkB-like proteins could be to reverse such modifications.
On the basis of the preferential specificity of AlkB-dependent repair for ssDNA and for SN2 as opposed to SN1 alkylating agents, it has been proposed that its targets include modified bases such as N 1-methyladenine and N 3-methylcytosine [ 18].
Seventeen ALDH genes have been identified in the human genome and have been classified into ten different families based on amino acid sequence identities [ 1 2 ] . High levels of ALDH1A1 activity can protect human and murine cells from the toxicity of the alkylating agent cyclophosphamide and its oxazaphosphorine analogs.
3 region to which RASSF1A maps undergoes deletions in many solid tumor types, including GCTs [ 9 ] . RASSF1A encodes a splice variant of human RAS effector homologue, which interacts with the XPA protein and functions as a negative regulator of cell growth [ 16 17 ] . RASSF1A has been shown to be inactivated by promoter methylation in a variety of tumor types [ 16 17 18 19 ] . The 17q21 and 17p13 regions, to which BRCA1 and HIC1 map, respectively, also have been characterized by high frequency of LOH in GCT [ 9 ] . The BRCA 1 gene plays critical roles in DNA repair and recombination, cell cycle checkpoint control, and transcription and has been shown to be hypermethylated in breast-ovarian cancer [ 4 ] . The HIC1 gene is also often hypermethylated in many human cancers [ 20 21 22 ] . The DNA repair gene MGMT encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 23 ] . Epigenetic inactivation of the MGMT gene was reported in a wide variety of cancers [ 24 25 ] . Also, a low frequency of methylation of the APC , RARB , and FHIT genes was detected in NSGCTs.
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