Example sentences for: alkylating

How can you use “alkylating” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our current observation that undetectable levels of MGMT gene expression in >95% of GCTs appears to suggest that the lack of the O(6)-methylguanine-DNA methyltransferase enzyme may direct cells to undergo apoptosis due to failure of repair of DNA adducts formed by alkylating agents.

  • AlkB binds ssDNA and is required for the processing of toxic DNA modifications caused by SN2 alkylating agents such as methylmethanesulfonate (MMS) specifically on ssDNA.

  • Given the importance of the MGMT protein in treatment response to alkylating agents, this molecular switch may play a critical role in sensitivity to cisplatin-based therapy in GCTs.

  • Given the presence of RNA methylases that could modify RNA in a similar way as the alkylating agents the function of the uncharacterized AlkB-like proteins could be to reverse such modifications.

  • On the basis of the preferential specificity of AlkB-dependent repair for ssDNA and for SN2 as opposed to SN1 alkylating agents, it has been proposed that its targets include modified bases such as N 1-methyladenine and N 3-methylcytosine [ 18].


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast