Words similar to alkylating
Example sentences for: alkylating
How can you use “alkylating” in a sentence? Here are some example sentences to help you improve your vocabulary:
MGMT gene encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 33 ] . Epigenetic gene silencing of MGMT confers enhanced sensitivity to alkylating-based chemotherapy, and lack of methylation associates with failure to respond to chemotherapy [ 34 35 ] . On the contrary, all patients that had MGMT promoter methylation were dead within 21 months of initial diagnosis, which predicts a poor prognosis.
The prodrug TLK286 [γ-glutamyl-α-amino-β(2-ethyl-N,N,N,N-tetrakis(2-chloroethyl)phosphorodiamidate)-sulfonyl-propionyl-(R)-(-)phenylglycine] is activated by glutathione S-transferase (GST) P1-1 and to a lesser degree A1-1 and generates tetrakis chloroethyl alkylating moieties that can react with cellular nucleophiles.
Seventeen ALDH genes have been identified in the human genome and have been classified into ten different families based on amino acid sequence identities [ 1 2 ] . High levels of ALDH1A1 activity can protect human and murine cells from the toxicity of the alkylating agent cyclophosphamide and its oxazaphosphorine analogs.
Given the importance of the MGMT protein in treatment response to alkylating agents, this molecular switch may play a critical role in sensitivity to cisplatin-based therapy in GCTs.
On the basis of the preferential specificity of AlkB-dependent repair for ssDNA and for SN2 as opposed to SN1 alkylating agents, it has been proposed that its targets include modified bases such as N 1-methyladenine and N 3-methylcytosine [ 18].
Loading...