Words similar to alkaloids
Example sentences for: alkaloids
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Aframomum melegueta has been previously recorded as a stimulant [ 50 ] . Caribs of Dominica used Aframomum granum-paradisi leaves on their bodies while they were bathing and the plant was also given to their hunting dogs [ 16 ] . Seeds were put into rum as a 'chauffe' to excite dogs [ 16 ] . Aframomum granum-paradisi contains alkaloids (piperine), essential oils and resins [ 54 ] .
Stimulation of the immune system might also contribute to reducing the effects of snakebites and improvement in recovery from envemomization by contributing to a more rapid removal of the venom [ 11 ] . Chlorogenic acid acts as an antidote by binding to proteins through hydrophobic interactions and hydrogen bonds [ 41 ] . It presents anticomplementary action at the classical pathway [ 41 ] . Analgesic properties like those provided by tropane alkaloids would also lessen the pain of the bite, as would compounds that act as sedatives and tranquilisers [ 40 ] .
Siparuma guianensis wood contains oxoaporphine alkaloids (liriodenine and cassamedine) [ 128 ] . The leaves contain an essential oil consisting of furanosesquiterpenes (mainly cruzerenones), myristicin (8%) and cruzerene (0.
utilis) that produce a dose-related increase in the clotting time of blood induced by carpet viper venom ( Echis carinatus ) would be useful against bites from Bothrops species that cause haemorrhage at the point of injection due to the inhibition of the clotting mechanism [ 40 ] . Antivenom compounds so far isolated from plants include protocatechuic acid, a catechin-gallo-catechin tannin, caffeic acid derivatives (chlorogenic acid, cynarin), coumarins (bergapten), flavonoids (rutin, isoscutellarein, kaempferol, quercetin, hesperidin), ar-turmerone, alkaloids (aristolochic acid), triterpenoids, triterpenes, coumestans (wedelolactone), sterols (sitosterol, stigmasterol, beta-amyrin), triterpenoid glycosides, alkaloids (allantoin) and lignoflavonoids [ 43 40 44 42 ] . Many relevant compounds are widely distributed nitrogen-free, low molecular weight compounds (except aristolochic acid, an untypical non-basic, nitro-derivative) [ 38 ] . The structural similarities of certain plant chemicals found in plants used for snakebites are an isoflavone skeleton, acidic nature and dioxygenated functionality [ 44 ] .
Because of the high catalytic efficiency and broad substrate specificity, β-lactamases have been extensively used in the ADEPT approach to activate prodrugs of vinca alkaloids [ 27 ] , nitrogen mustard [ 28 29 30 31 32 ] , doxorubicin [ 33 34 35 36 ] and others [ 37 ] . To take advantage of the potent antitumor activity of the CC-1065 class of compounds and the ADEPT approach, we have synthesized β-lactam prodrugs.
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