Example sentences for: aliphatic

How can you use “aliphatic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Mutating the conserved leucine to arginine at position 156 is a drastic change, disrupting a γ-branched aliphatic residue with a basic guanidino group, a major chemical and presumably structural substitution.

  • They include: (1) sulfate esters of polysaccharides {carrageenan [ 1 16 17 18 19 ] , cellulose sulfate [ 12 13 14 15 ] , and dextran or dextrin sulfate [ 1 2 3 4 5 6 7 8 9 10 11 ] }; (2) aryl sulfonates {poly(naphthalene sulfonate) [ 22 23 24 ] and poly(styrene-4-sulfonate) [ 20 21 ] }; and (3) aliphatic {Carbomer 974P/BufferGel [ 25 26 27 28 29 ] } and aromatic carboxylates {CAP [ 30 31 32 33 34 35 36 37 ] }. The anti-HIV-1 properties of these polymers are expected to depend on their complexation with virus proteins which is likely to occur mainly through the formation of salt linkages or ion pairs between oppositely charged groups on the polymers and virus proteins, respectively [ 56 ] . However, the anti-HIV-1 properties of these polymers may depend not only on their charge density, but also on the characteristics of their uncharged portions, which may be involved in hydrophobic and hydrogen bonding interactions which can elicit profound conformational changes in hydrophobic regions of proteins and cause disassembly of complex proteins consisting of subunits [ 57 ] . For these reasons it is not be expected that all anionic polymers, considered as anti-HIV-1 microbicides, would have similar biological activities.

  • The aliphatic portions of the side chains of both Lys61's may play roles in RNA binding since they cross the faces of both adenosines.

  • However, the data from this and other [ 22 29 ] studies suggest a clear preference for phenyl or aliphatic side chains (F, Y, L, I, V, M) in the +1 position.

  • It is notable that the K61M substitution, which was designed to preserve the aliphatic characteristics of the lysine side chain while eliminating its amino group, causes a severe repressor defect in mutant homodimers.


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