Words similar to agrp

Example sentences for: agrp

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For example, it is clear that the regulation of AGRP differs in rats and mice, since in mice hypothalamic AGRP mRNA is elevated by a deficiency in leptin receptor function [ 4 ] but in rats this is not true [ 21 ] . However, hypothalamic POMC is regulated similarly in rats and mice, and this is probably the more important element regulating metabolic phenotype.
However, the corticosterone implants produced the unexpected effect of elevating hypothalamic POMC mRNA, a rare if not unique circumstance in which hypothalamic AGRP and POMC mRNA are regulated in the same direction.
Adrenalectomy also produced a trend to decrease AGRP mRNA in the ad-lib fed mice but this effect was not significant (Fig.
Hypothalamic proopiomelanocortin (POMC) and agouti-related peptide (AGRP) mRNA and pituitary POMC mRNA were measured by Northern blot analysis as previously described [ 6 ] . Briefly, total RNA was extracted in TRIzol (GIBCO BRL, Gaithersburg, MD) and three micrograms of total RNA from hypothalamus, estimated by spectrophotometer and verified by gel electrophoresis, was subjected to Northern blot analysis to measure POMC and AGRP mRNA.
These data suggest that in fasting and insulin-deficient diabetes, as in leptin-deficient ob/ob mice [ 9 19 ] , glucocorticoids dominate leptin and insulin levels in determining AGRP expression, whereas insulin and leptin dominate glucocorticoids in determining hypothalamic POMC expression.