Words similar to age-bsa

Example sentences for: age-bsa

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Pan-caspase inhibitor z-VAD-fmk and the specific caspase 3 inhibitor z-DEVD-fmk prevented apoptosis induced by PA and AGE-BSA, while the specific caspase 9 inhibitor z-LEHD-fmk had no significant inhibitor effect (Figure 5G).
In contrast, AGE-BSA significantly increased apoptotic nuclei compared with unglycated BSA in MCT PTECs transiently transfected with CD36 expression vector (Figure 6).
Chemical inhibition of p38 MAPK prevented the increase in the rate of apoptotic nuclei induced by both AGE-BSA5 and PA in HK-2 PTECs (Figure 5G), indicating that p38 MAPK function is required for apoptosis induced by AGE-BSA and PA through CD36 receptor.
In contrast with CD36-positive human HK-2 PTECs, we found that treatment of CD36-negative mouse MCT PTECs with AGE-BSA had no effect on rates of apoptotic nuclei (data not shown).
Our finding that AGE-BSA and PA induce apoptosis through a CD36-mediated and p38- and caspase-dependent mechanism in tubular epithelial cells, similar to TSP-1 and ox-LDL in endothelial cells and macrophages, respectively, suggests that multiple, context-dependent extracellular stimuli of apoptosis may converge on CD36 scavenger receptor to activate src kinase and proapoptotic p38 MAPK pathway.