Words similar to age-bsa

Example sentences for: age-bsa

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Our finding that AGE-BSA and PA induce apoptosis through a CD36-mediated and p38- and caspase-dependent mechanism in tubular epithelial cells, similar to TSP-1 and ox-LDL in endothelial cells and macrophages, respectively, suggests that multiple, context-dependent extracellular stimuli of apoptosis may converge on CD36 scavenger receptor to activate src kinase and proapoptotic p38 MAPK pathway.
To test whether CD36 was sufficient to mediate AGE-BSA-induced apoptosis, we transfected CD36-negative mouse MCT PTECs with a plasmid expressing human CD36 or empty control vector, followed by treatment with control BSA or AGE-BSA5.
Thus, transgenic de novo expression of human CD36 in CD36-negative mouse PTECs was sufficient to mediate apoptosis induced by AGE-BSA.
Taken together, our findings demonstrate that pathophysiologically relevant species of AGE-BSA and CML-BSA, as well as saturated FFA PA, induce apoptosis in human PTECs at concentrations previously observed in plasma and/or urine in humans with diabetes.
Pan-caspase inhibitor z-VAD-fmk and the specific caspase 3 inhibitor z-DEVD-fmk prevented apoptosis induced by PA and AGE-BSA, while the specific caspase 9 inhibitor z-LEHD-fmk had no significant inhibitor effect (Figure 5G).