Words similar to age-bsa
Example sentences for: age-bsa
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Chemical inhibition of p38 MAPK prevented the increase in the rate of apoptotic nuclei induced by both AGE-BSA5 and PA in HK-2 PTECs (Figure 5G), indicating that p38 MAPK function is required for apoptosis induced by AGE-BSA and PA through CD36 receptor.
CD36 Is Sufficient to Mediate Apoptosis Induced by AGE-BSA and FFA
Treatment with AGE-BSA for 2, 5, or 10 wk or with CML-BSA induced a significant increase in the number of apoptotic nuclei in CD36-positive HK-2 cells compared with control BSA-treated or untreated HK-2 cells (Figure 4A).
Therefore we examined phospho-src, phospho-p38 levels and caspase 3 activation in HK-2 PTECs treated with AGE-BSA and PA in the absence or presence of anti-CD36 neutralizing antibody.
Taken together, our findings demonstrate that pathophysiologically relevant species of AGE-BSA and CML-BSA, as well as saturated FFA PA, induce apoptosis in human PTECs at concentrations previously observed in plasma and/or urine in humans with diabetes.
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