Words similar to age-bsa

Example sentences for: age-bsa

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Pan-caspase inhibitor z-VAD-fmk and the specific caspase 3 inhibitor z-DEVD-fmk prevented apoptosis induced by PA and AGE-BSA, while the specific caspase 9 inhibitor z-LEHD-fmk had no significant inhibitor effect (Figure 5G).
Exposure of human HK-2 and murine M1 cell lines to defined preparations of FFA PA or AGE-BSA had no effect on CD36 mRNA and protein expression levels (data not shown).
These findings indicate that CD36 activates proapoptotic p38 MAPK possibly via src kinase activation in human PTECs when stimulated with AGE-BSA5 and PA.
Together these findings indicate that CD36 receptor mediates sequential phosphorylation of src kinases and p38 MAPK, leading to activation of caspase 3 and apoptosis in human PTECs exposed to AGE-BSA and PA ligands.
AGE-BSA5-induced apoptosis was blocked when cells were preincubated with neutralizing anti-CD36 antibody, while preincubation with control IgG antibody had no effect (Figure 4A).