Words similar to adoptively

Example sentences for: adoptively

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It is possible that radiation-induced, tumor-infiltrating dendritic cells may facilitate sustained activation and infiltration of the adoptively transferred CD4 +T cells in solid tumors in the combination group.
Collectively, these data indicate that neither hCARΔcyt or GFP expression nor adenoviral transduction affects survival or trafficking of adoptively transferred cells for at least 4 days in vivo.
As a control, the same number of CD4 +CD25 -T cells, together with arthritogenic spleen cells that were depleted of CD25 +cells, and proteoglycan, were also adoptively transferred into SCID mice.
We observed no decrement in GFP expression by adoptively transferred cells as long as 4 days following transfer (data not shown), but have not yet examined later time points.
Previous studies have shown that adoptively transferred tumor antigen-specific CD4 +T cells can be tolerized in the secondary lymphoid organs [ 9 34 ] , including the RIP-Tag2 model [ 30 ] . Radiation may kill or disable regulatory T cells [ 35 36 ] , or other bone marrow-derived tolerizing cells and prevent the induction of tolerance in adoptively transferred tumor-specific T cells [ 9 ] . Additionally, the high but sub-lethal dose of radiation used leads to significant lymphopenia [ 37 ] . The sudden reduction in lymphocyte number may create the spatial allowance in spleen and lymph nodes necessary for the homing, activation and expansion of he adoptively-transferred T cells.