Words similar to adoptively

Example sentences for: adoptively

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Previous studies have shown that adoptively transferred tumor antigen-specific CD4 +T cells can be tolerized in the secondary lymphoid organs [ 9 34 ] , including the RIP-Tag2 model [ 30 ] . Radiation may kill or disable regulatory T cells [ 35 36 ] , or other bone marrow-derived tolerizing cells and prevent the induction of tolerance in adoptively transferred tumor-specific T cells [ 9 ] . Additionally, the high but sub-lethal dose of radiation used leads to significant lymphopenia [ 37 ] . The sudden reduction in lymphocyte number may create the spatial allowance in spleen and lymph nodes necessary for the homing, activation and expansion of he adoptively-transferred T cells.
Collectively, these data indicate that neither hCARΔcyt or GFP expression nor adenoviral transduction affects survival or trafficking of adoptively transferred cells for at least 4 days in vivo.
It is possible that radiation-induced, tumor-infiltrating dendritic cells may facilitate sustained activation and infiltration of the adoptively transferred CD4 +T cells in solid tumors in the combination group.
We observed no decrement in GFP expression by adoptively transferred cells as long as 4 days following transfer (data not shown), but have not yet examined later time points.
As a control, the same number of CD4 +CD25 -T cells, together with arthritogenic spleen cells that were depleted of CD25 +cells, and proteoglycan, were also adoptively transferred into SCID mice.