Example sentences for: adipocyte

How can you use “adipocyte” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • One possibility is that hormones secreted by adipocytes compromise peripheral insulin sensitivity, and a number of candidates for such adipocyte signals have been identified.

  • They proliferated rapidly in culture, had an adherent, spread morphology, displayed cytoskeletal, cytoplasmic, and surface markers of mesenchymal precursors, and had a capacity for differentiation into fibroblast, osteoblast, and adipocyte lineages.

  • Leptin production is primarily regulated by insulin-induced changes in adipocyte metabolism—its secretion levels correlate with adipocyte mass and lipid loads.

  • Potential mechanisms for altered adipocyte function include, direct binding to PPARgamma or inhibition of transcription of PPARgamma promoter [ 37 ] . The lipodystrophy syndrome may be a result of the inhibition of 2 proteins involved in lipid metabolism that have significant homology to the catalytic site of HIV proteases; namely cytoplasmic retinoic acid binding protein type 1 and low density lipoprotein-receptor-related protein [ 38 ] . An additional mechanism of PPAR down-regulation may be related to Tat expression in latent cells.

  • C/EBPα binds to and activates transcription of the gene promoter for the p21 inhibitor of cyclin-dependent kinase (CDK) [ 37 ] . This led to speculation that p21 gene activation may contribute to cell cycle arrest by C/EBPα [ 37 ] . Similarly, suppression of mitotic growth during adipocyte differentiation was associated with C/EBPα activation of the promoters of gadd45 (growth arrest and DNA damage-inducible gene 45), gas2 and gas3 (growth arrest-associated genes 2 and 3) [ 5 6 38 39 ] . However, C/EBPα mutants defective in DNA binding still blocked proliferation [ 25 33 ] . This suggested that direct promoter activation was unnecessary, or redundant, for C/EBPα proliferation arrest [ 18 ] .

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