Words similar to adipocyte
Example sentences for: adipocyte
How can you use “adipocyte” in a sentence? Here are some example sentences to help you improve your vocabulary:
While habitual physical activity promotes a great variety of physiological adaptations that alter vascular reactivity, cardiac function, adipocyte function, and neurophysiology, adaptive responses of skeletal myofibers confer at least some of the health benefits.
Leptin production is primarily regulated by insulin-induced changes in adipocyte metabolism—its secretion levels correlate with adipocyte mass and lipid loads.
Dexamethasone at 10 -9mol/l supports adipocyte differentiation, whereas osteogenesis is favored at 10 -7mol/l [ 19].
Potential mechanisms for altered adipocyte function include, direct binding to PPARgamma or inhibition of transcription of PPARgamma promoter [ 37 ] . The lipodystrophy syndrome may be a result of the inhibition of 2 proteins involved in lipid metabolism that have significant homology to the catalytic site of HIV proteases; namely cytoplasmic retinoic acid binding protein type 1 and low density lipoprotein-receptor-related protein [ 38 ] . An additional mechanism of PPAR down-regulation may be related to Tat expression in latent cells.
C/EBPα binds to and activates transcription of the gene promoter for the p21 inhibitor of cyclin-dependent kinase (CDK) [ 37 ] . This led to speculation that p21 gene activation may contribute to cell cycle arrest by C/EBPα [ 37 ] . Similarly, suppression of mitotic growth during adipocyte differentiation was associated with C/EBPα activation of the promoters of gadd45 (growth arrest and DNA damage-inducible gene 45), gas2 and gas3 (growth arrest-associated genes 2 and 3) [ 5 6 38 39 ] . However, C/EBPα mutants defective in DNA binding still blocked proliferation [ 25 33 ] . This suggested that direct promoter activation was unnecessary, or redundant, for C/EBPα proliferation arrest [ 18 ] .
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