Words similar to acr
Example sentences for: acr
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Except for the tender-joint count, none of the observed disease activities was statistically different from placebo according to the ACR criteria at the 20% improvement level.
An analogous genetic system ( Arr or ACR ) has also been described in the eukaryote Saccharomyces cervisiae [ 24 ] . Thus the ars operon, or similar arsenic resistance systems, appears to be relatively widespread throughout microorganisms.
The changes of D62 on ACR1, E174 on ACR3, D213 (D219 in HB6) and S218 on ACR4 dramatically decrease both ATPase and ADPase activities of CD39 [ 12 15 ] . Figure 7summarizes the possible coordination of Ca 2+from the data of species T, species D1, and species D2 in the different situations of sCD39 catalysis.
NTPDases do not form phosphorylated intermediates during catalysis, a conclusion also supported by lack of vanadate sensitivity and Pi product inhibition [ 3 4 5 6 ] . The catalytic reaction appears to be irreversible and no partial reactions have been observed [ 7 8 ] . Divalent cations like Ca 2+or Mg 2+are required for activity, and maximal activity is reached when the concentrations of substrates and divalent cations are equal [ 1 ] . The specific activities of NTPDases vary over a broad range from ten thousand units for potato apyrase to less than one hundred units for chicken gizzard ecto-ATPase [ 9 10 ] . Sequence comparisons indicate that most of NTPDases contain five highly conserved regions, apyrase conserved region, ACR1 - ACR5 [ 9 11 ] . However, the catalytic sites have not been identified, although ACR1 and ACR4 have been implicated in β- and γ-phosphate binding, respectively [ 9 ] .
Residues of ACR1 to ACR5 of CD39 have been mutated to study the involvement of the ACR regions in catalysis.
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