Words similar to acr
Example sentences for: acr
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NTPDases do not form phosphorylated intermediates during catalysis, a conclusion also supported by lack of vanadate sensitivity and Pi product inhibition [ 3 4 5 6 ] . The catalytic reaction appears to be irreversible and no partial reactions have been observed [ 7 8 ] . Divalent cations like Ca 2+or Mg 2+are required for activity, and maximal activity is reached when the concentrations of substrates and divalent cations are equal [ 1 ] . The specific activities of NTPDases vary over a broad range from ten thousand units for potato apyrase to less than one hundred units for chicken gizzard ecto-ATPase [ 9 10 ] . Sequence comparisons indicate that most of NTPDases contain five highly conserved regions, apyrase conserved region, ACR1 - ACR5 [ 9 11 ] . However, the catalytic sites have not been identified, although ACR1 and ACR4 have been implicated in β- and γ-phosphate binding, respectively [ 9 ] .
At the completion of the year of observation, patients who were diagnosed as having RA had all met the 1987 American College of Rheumatology (ACR) criteria [ 27] on at least one visit.
ACR = American College of Rheumatology; CRP = C-reactive protein; DMARD = disease-modifying antirheumatic drug; IL = interleukin; NF = nuclear factor; RA = rheumatoid arthritis; rhIL-11 = recombinant human IL-11; TNF = tumor necrosis factor.
Except for the tender-joint count, none of the observed disease activities was statistically different from placebo according to the ACR criteria at the 20% improvement level.
The changes of D62 on ACR1, E174 on ACR3, D213 (D219 in HB6) and S218 on ACR4 dramatically decrease both ATPase and ADPase activities of CD39 [ 12 15 ] . Figure 7summarizes the possible coordination of Ca 2+from the data of species T, species D1, and species D2 in the different situations of sCD39 catalysis.
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