Words similar to acetyltransferase
Example sentences for: acetyltransferase
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The available research regarding cognitive function and phytoestrogens suggests that large amounts of phytoestrogens, consumed as tofu, have an adverse influence on cognitive ability in men, where decreased brain weight, increased ventricular size and dementia have been reported [ 44 ] . In ovariectomized female rats, on the other hand, phytoestrogen treatments resulted in a dose-dependent improvement of VSM [ 45 ] . This improvement in cognitive ability in phytoestrogen treated females may be due in part to the increased presence of choline acetyltransferase messenger RNA in the frontal cortex, which has been shown to be associated with protection and enhancement of cognitive function [ 45 ] . Furthermore, we have shown that phytoestrogens significantly affect the brain calcium-binding protein calbindin (CALB), which acts as a buffer by binding intracellular calcium and plays an important role in mediating cell proliferation, programmed cell death (apoptosis), and neurotoxicity [ 48 49 50 51 52 ] . This neuroprotective mechanism via CALB appears to be important in neurological disorders such as Parkinson's disease and Huntington's disease [ 48 49 50 51 52 ] . Additionally, Cyclooxygenase-2 (COX-2) seems to play an important role in mediating functional neuronal maturation and responses to certain stimuli in the brain [ 53 54 55 ] . The expression of COX-2 is associated with key pathophysiologic events in Alzheimer's disease: deposition of beta-amyloid protein in neuritic plaques within the hippocampus and cortex [ 53 54 55 ] . Of particular importance to this study is the fact that COX-2 has been shown to be influenced by steroidal hormones [ 53 54 55 ] . Therefore, the expression of COX-2 in the frontal cortex may also be hormonally regulated and relevant to cognitive decline.
Aside from induction of ICER, Tat is capable of forming complex (es) with a component of TFIID, TAF II 250 [ 24 ] and Tip60 [ 25 ] both of which contain histone acetyltransferase (HAT) activity.
In experiments designed to isolate ATF-2-associated HAT, ATF-2 alone was shown to be sufficient for the acetyltransferase activity.
The genes included: Rv3052c (probable nrdI ) which is postulated to be involved in deoxynucleotide production under stressed conditions; Rv0101 which is a nonribosomal peptide synthetase that displays strong homology with a Pseudomonas nonribosomal peptide synthetase required for the synthesis of the pyoveridine, a siderophore involved in iron uptake; Rv3420c which displays homology with the S18 ribosomal protein acetyltransferase which behaves as a heat shock protein in Chlamydia trachomatis; and Rv0497 and Rv3604c which are hypothetical conserved membrane proteins of unknown function.
For studies of the transcriptional activation properties of the fusion proteins, 1 μg of the C/EBP-TATA vector [ 45 ] was co-transfected and transcriptional activity was assessed by measuring the amount of chloramphenicol acetyltransferase reporter expressed with and without C/EBPα expression [ 45 ] .
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