Words similar to abp-tg
Example sentences for: abp-tg
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Between Days 21 and 60, the number of S-phase cells undergoing apoptosis was significantly higher in ABP-TG than in control mice.
Our earlier findings including a reduced number of elongated spermatids in the ABP-TG mice [ 26 ] also support the notion that higher than physiological concentrations of ABP affect spermatogenesis indirectly, through sequestration of androgens; the transformation of round spermatids to elongated spermatids is known to be the main androgen-dependent step in spermatogenesis [ 35 36 37 ] .
The general pattern of germ cells undergoing apoptosis in ABP-TG mice was similar; however, the total number of germ cells undergoing apoptosis in ABP-TG mice was consistently higher than in controls on Days 21, 30 and 60, respectively (the increase was statistically significant on Days 21 and 30).
It is well established that TG mice overexpressing rat ABP [ 22 ] develop a testicular impairment [ 23 24 25 ] leading gradually to a reduced number of germ cells and infertility [ 26 ] . Various theories were proposed to explain the possible mechanisms behind this testicular impairment seen in the ABP-TG mice overexpressing rat ABP.
[ 51 ] described meiotic arrest and an "increased occurrence of apoptosis" of testicular germ cells (primarily pachytene spermatocytes and cells in metaphase) in 3-, 6-, and 12-month old ABP-TG mice and suggested that these events were the cause of the fertility impairment seen in these animals.
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