Words similar to abp
Example sentences for: abp
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Thus, available evidence does not seem to indicate a direct inhibitory or "damaging" role of ABP in spermatogenesis.
Since the most likely mechanism of this effect of ABP is androgen sequestration, androgens are likely to play an important role in regulating the wave of germ cell apoptosis in mice.
The late stages of spermatogenesis (spermiogenesis) were extensively studied for the possible direct effects of ABP [ 16 17 42 43 44 45 ] . In these studies, however, ABP (at least at physiological concentrations) appeared to be supportive, rather than detrimental, to spermatogenesis.
Our earlier findings including a reduced number of elongated spermatids in the ABP-TG mice [ 26 ] also support the notion that higher than physiological concentrations of ABP affect spermatogenesis indirectly, through sequestration of androgens; the transformation of round spermatids to elongated spermatids is known to be the main androgen-dependent step in spermatogenesis [ 35 36 37 ] .
Taken together, the presence of increased levels of intra-testicular ABP in the TG mice after 7 days of age [ 25 26 ] and a wave of germ cell apoptosis seen in normal mice at 21 and 30 days of age in this study and by Rodriguez et al . [ 3 ] suggest that the heightened apoptotic wave found in our TG mice during the pre-pubertal period may be regulated by ABP.
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