Words similar to abp
Example sentences for: abp
How can you use “abp” in a sentence? Here are some example sentences to help you improve your vocabulary:
The increased concentration of ABP present in the testes of TG mice (see Joseph et al . [ 25 ] ) will chronically reduce the concentration of intra-testicular free T available for interaction with androgen receptor (AR) and other molecular targets.
, [ 10 12 13 14 15 ] ]. It is thought to regulate spermatogenesis and sperm maturation by maintaining high androgen levels in the testis and epididymis [ 16 17 ] and has been proposed as a biochemical marker for Sertoli cell function and formation of blood-testis barrier [ 12 18 ] . More recently, cell surface receptors for ABP and its liver-derived homolog sex hormone-binding globulin (SHBG) were identified in several androgen target tissues, suggesting that these extracellular steroid-binding proteins may have a much broader, hormone-like function [ 19 20 21 ] .
Since the most likely mechanism of this effect of ABP is androgen sequestration, androgens are likely to play an important role in regulating the wave of germ cell apoptosis in mice.
Taken together, the presence of increased levels of intra-testicular ABP in the TG mice after 7 days of age [ 25 26 ] and a wave of germ cell apoptosis seen in normal mice at 21 and 30 days of age in this study and by Rodriguez et al . [ 3 ] suggest that the heightened apoptotic wave found in our TG mice during the pre-pubertal period may be regulated by ABP.
Our earlier findings including a reduced number of elongated spermatids in the ABP-TG mice [ 26 ] also support the notion that higher than physiological concentrations of ABP affect spermatogenesis indirectly, through sequestration of androgens; the transformation of round spermatids to elongated spermatids is known to be the main androgen-dependent step in spermatogenesis [ 35 36 37 ] .
Loading...