Words similar to abp
Example sentences for: abp
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Thus, available evidence does not seem to indicate a direct inhibitory or "damaging" role of ABP in spermatogenesis.
Apoptotic cells were identified by the TdT-mediated dUTP-biotin nick end labeling (TUNEL) method and detected either by flow cytometry [ 27 ] or by light microscopy in histological sections [ 28 ] . The results indicate that transgenic ABP alters the rate of testicular germ cell apoptosis throughout life, but it is most likely to cause its germ-cell depleting effect by promoting germ cell apoptosis during the critical pre-pubertal period ("puberty" in laboratory rodents occurs at 50-60 days of life and is defined as the first appearance of spermatozoa in the tail of the epididymis [ 29 30 ] ).
Thus, at Days 21, 30, and 60, the changes observed must be directly related to the increased levels of testicular ABP present in these TG animals.
Taken together, the presence of increased levels of intra-testicular ABP in the TG mice after 7 days of age [ 25 26 ] and a wave of germ cell apoptosis seen in normal mice at 21 and 30 days of age in this study and by Rodriguez et al . [ 3 ] suggest that the heightened apoptotic wave found in our TG mice during the pre-pubertal period may be regulated by ABP.
This is supported by the in vitro study of Roberts and Zirkin [ 34 ] demonstrating that ABP can actually inhibit T's action at the level of the AR.