Words similar to abasic

Example sentences for: abasic

How can you use “abasic” in a sentence? Here are some example sentences to help you improve your vocabulary:

The 3' approach to the DNA [ 34 ] and the wide area covered by the protein on both sides of the abasic site [ 14 ] are both consistent with the need to hold the product until the correct polymerase moves in 5' to 3' to complete the repair [ 25 ] . This implies that the mammalian enzyme has evolved to be processive, to facilitate more efficient functioning of the overall BER pathway, and may not be optimized for simple catalysis.
The endonuclease activity of DNase 1 is reduced many fold by integrating this loop from E. coli exonuclease III, but the mutant cleaves at abasic sites in DNA with low efficiency [ 29 ] . Thus additional residues in the APEs control specificity while still allowing a reasonable rate of phosphorolytic cleavage.
APEs are essential for mammalian cell growth and bacterial survival in the presence of ionizing radiation and DNA mutagens [ 6 ] . They initiate repair of an abasic DNA site by cleaving the phosphodiester backbone 5' of the phosphodeoxyribose.
Although motif 12 contains several highly conserved residues that, according to mutagenesis results (Table 1) contribute to APE1 activity, only His309 is very close to the abasic site in the DNA.
This redundancy of binding to the 3' side is unique to APE, as is its strong binding to the DNA opposite the abasic site.