Words similar to abasic

Example sentences for: abasic

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A contact plot of huAPE1 with the DNA in the 1DE8 crystal structure (Figure 5) shows that motifs 1-3,5-8, and 10-12 all have residues close to the substrate, an oligonucleotide containing an abasic site (AP-DNA).
This redundancy of binding to the 3' side is unique to APE, as is its strong binding to the DNA opposite the abasic site.
This generates the necessary 3' hydroxyl group for DNA polymerases (pol β, δ or ε, in eukaryotes) to insert the correct nucleotide in later steps in the base excision repair pathway (BER-pathway) [ 7 8 ] . Recent crystal structures of huAPE1 complexed with DNA containing an abasic site [ 9 10 11 ] , combined with sequence analysis and site-directed mutagenesis, have defined the residues that participate in metal ion based cleavage of the phosphate backbone of the DNA [ 12 13 14 15 16 17 ] .
The 3' approach to the DNA [ 34 ] and the wide area covered by the protein on both sides of the abasic site [ 14 ] are both consistent with the need to hold the product until the correct polymerase moves in 5' to 3' to complete the repair [ 25 ] . This implies that the mammalian enzyme has evolved to be processive, to facilitate more efficient functioning of the overall BER pathway, and may not be optimized for simple catalysis.
Is the specificity of APE determined by binding 3' to an abasic site?