Example sentences for: abasic

How can you use “abasic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • P2s have two abasic residues at the 5' end to reduce primer-dimer formation (unpublished data).

  • We have used abasic residues at the 5' ends of P2 primers in order to reduce these artifacts.

  • The residues contacting the region 3' to the abasic site come from three different uniquely conserved areas of APEs (molegos 6,7a, 10) as well as 11, a molego that is similar to that in DNase-1.

  • This generates the necessary 3' hydroxyl group for DNA polymerases (pol β, δ or ε, in eukaryotes) to insert the correct nucleotide in later steps in the base excision repair pathway (BER-pathway) [ 7 8 ] . Recent crystal structures of huAPE1 complexed with DNA containing an abasic site [ 9 10 11 ] , combined with sequence analysis and site-directed mutagenesis, have defined the residues that participate in metal ion based cleavage of the phosphate backbone of the DNA [ 12 13 14 15 16 17 ] .

  • This redundancy of binding to the 3' side is unique to APE, as is its strong binding to the DNA opposite the abasic site.


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