Words similar to abasic

Example sentences for: abasic

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Is the specificity of APE determined by binding 3' to an abasic site?
An alanine substitution mutant, N226A, of a conserved residue at the end of molego 7a that forms a hydrogen bond with the second phosphate group downstream of the abasic site, had enhanced APE activity but increased Km and Kd values, similar to an alanine mutant of R177, which binds to the same site, reported previously [ 34 ] . A combination of the two mutants, N226A and R177A, substantially reduced the ability of APE1 to bind to DNA containing an abasic site (Izumi et al.
APEs are essential for mammalian cell growth and bacterial survival in the presence of ionizing radiation and DNA mutagens [ 6 ] . They initiate repair of an abasic DNA site by cleaving the phosphodiester backbone 5' of the phosphodeoxyribose.
The residues contacting the region 3' to the abasic site come from three different uniquely conserved areas of APEs (molegos 6,7a, 10) as well as 11, a molego that is similar to that in DNase-1.
The abasic sugar-phosphate backbone is then cleaved by an apurinic/apyrimidinic endonuclease or lyase.