Example sentences for: pdtc

How can you use “pdtc” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Alternatively, a pseudomonad ancestor could have contained the genes for and produced pdtc, but this function could have been lost from most strains.

  • Loss of this function is plausible if pdtc production is a highly specialized function or is only required for survival in extreme or competitive environments.

  • An open reading frame (ORF-F) identified as a necessary part of the Pseudomonas stutzeri pdt locus coding for the synthesis pathway of pdtc (Figure 1) was found to have 57% identity to M. tuberculosis MoeZ at the amino acid (AA) level.

  • Pyridine-2,6-bis(thiocarboxylic acid) (pdtc) is an iron-regulated metabolite produced by certain pseudomonads that is highly reactive towards metals by virtue of a pair of thiocarboxylate groups and ring nitrogen that combine to form a non-specific, high affinity, tri-dentate ligand (Figure 1) [ 1 2 ] . The formation constants for Co, Cu, and Fe complexes of pdtc were determined to be greater than 10 33 [ 3 ] . Uptake studies using 59Fe showed that addition of pdtc to the growth medium of two different pdtc-producing pseudomonads increased the efficiency of iron uptake by 20% [ 1 ] . The contribution of pdtc to iron uptake may be due to the fact that the copper complex of pdtc (Cu:pdtc) has the ability to reduce both soluble and mineral forms of ferric iron) [ 1 ] . Not surprisingly, in light of its high affinity for essential metals, pdtc also exhibits antimicrobial activity [ 4 ] .

  • MoeZ, on the other hand, has been shown to be necessary for the synthesis of pdtc, an unusual metabolite.


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