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Example sentences for: pdtc
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Three other P. stutzeri isolates, obtained from the American Type Culture Collection, have been shown by Southern analysis to lack pdtc synthesis genes.
These same strains plus P. aeruginosa PAO1, P. putida mt2, and P. fluorescens F113 were also shown not to produce pdtc [ 17 ] . Pdtc production in bacteria other than P. stutzeri strain KC is limited to
In either case, MoeZ is essential to pdtc synthesis in P. stutzeri strain KC, and pdtc is a potent and versatile molecule.
Pyridine-2,6-bis(thiocarboxylic acid) (pdtc) is an iron-regulated metabolite produced by certain pseudomonads that is highly reactive towards metals by virtue of a pair of thiocarboxylate groups and ring nitrogen that combine to form a non-specific, high affinity, tri-dentate ligand (Figure 1) [ 1 2 ] . The formation constants for Co, Cu, and Fe complexes of pdtc were determined to be greater than 10 33 [ 3 ] . Uptake studies using 59Fe showed that addition of pdtc to the growth medium of two different pdtc-producing pseudomonads increased the efficiency of iron uptake by 20% [ 1 ] . The contribution of pdtc to iron uptake may be due to the fact that the copper complex of pdtc (Cu:pdtc) has the ability to reduce both soluble and mineral forms of ferric iron) [ 1 ] . Not surprisingly, in light of its high affinity for essential metals, pdtc also exhibits antimicrobial activity [ 4 ] .
The CSC-induced increase in IL-1β expression was also reduced by treatment of the cells with PD98059 or the NFκB inhibitor, PDTC (Fig.
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