Example sentences for: pck

How can you use “pck” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Feeding of all three LC-PUFA diets led to an increase in hepatic Pck1 transcription, indicating gluconeogenesis was favored over glycolysis.

  • In the liver, cAMP regulates Pck1 transcription via the binding of CREB, as well as CCAAT/enhancer binding protein (C/EBP), to the CRU.

  • HNF3γ-signaling may regulate transcription of Pck1 (up regulated ca. 2* fold with each diet, presently), and G6pc (differentially regulated in the current experiment) [ 42 ] . HNF3γ is also reported to increase transcription of several genes that were not differentially regulated in the present experiment including, transferrin, tyrosine amino transferase [ 43 ] , and IPF-1/PDX-1 [ 40 ] .

  • The signaling pathways affecting Pck1 transcription are discussed in the section "cAMP signaling/links to carbohydrate metabolism".

  • Overall, LC-PUFA may up regulate Pck1, the rate-limiting enzyme in gluconeogenesis, via cAMP-, SREBP-1- and/or PPAR-signaling [ 57 ] . This has the overall effect of limiting fat accumulation and shunting metabolic flux to gluconeogenesis.


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