Words similar to overexpressing
Example sentences for: overexpressing
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It has been demonstrated that malignant tissues with accelerated cell cycle show higher levels of ProTα expression than normal or surrounding healthy tissues [ 67 ] . ProTα was shown as a marker for breast cancer [ 68 ] , hepatocarcinoma [ 69 ] , and plasma levels of its derivative Tα 1 been proposed as a marker for the prognosis of lung cancer [ 70 ] . In ligand blotting assays, ProTα bound only to chromatin pools and nuclear fractions where histone H1 was present [ 71 72 ] . The analysis of the interaction of ProTα with H1-containing chromatin suggests a putative role for ProTα in the fine-tuning of the stoichiometry and/or mode of interaction of H1 with chromatin [ 73 ] . Interestingly, HL-60 cells overexpressing ProTα show an enhancement of accessibility of micrococcal nuclease to chromatin, implying relaxed chromatin structure for enhanced cell cycle gene expression [ 74 ] .
Overexpression of the wild-type IGF-IRs increased the number of colonies, and overexpressing the kinase-defective receptors reduced the number of colonies by 60% (Figure 1C).
, 1998), it has been proposed that there is a need for caution in interpreting p53 function on the basis of cells transiently overexpressing this protein.
MC57 cells expressed COX-2 constitutively, consistent with the domination of the PG profile by PG E 2 . However, IDO overexpressing clone 26 showed a reduced amount of COX-2 protein compared to the vector only control (Fig 8C).
While additional measurements at later stages of development would be needed to confirm whether this is a continuous trend for cartilage development in late pregnancy in Hoxc-8 overexpressing animals, these results were initially unexpected: The phenotype of Hoxc-8 transgenic animals at 17.
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