Example sentences for: orthotopic

How can you use “orthotopic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The effect of TSP-1 expression on tumor growth and metastasis has been examined in vivo by orthotopic inoculation of TSP-1-overexpressing MDA-MB-435 cells.

  • The purpose of the study was to validate the newly derived postoperative orthotopic liver transplantation (OLTX)-specific diagnostic weight for APACHE II in independent databases.

  • APACHE = Acute Physiology and Chronic Health Evaluation; CI = confidence interval; GCS = Glasgow Coma Score; ICU = intensive care unit; OLTX = orthotopic liver transplantation; ROC = receiver operating characteristic; SMR = standardized mortality ratio.

  • In an effort to establish a methodological framework for analysis of the molecules and the mechanisms involved in this complex multistep process, we previously developed a well-defined experimental system in which the role of candidate genes can be screened and tested [ 2 ] . By serial dilution cloning of the MDA-MB-435 tumor cell line and screening by orthotopic implantation into the mammary fat pad of athymic mice, we derived a pair of breast tumor cell lines (M-4A4 and NM-2C5) that originate from the same breast tumor, but that have diametrically opposite metastatic capabilities.


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