Example sentences for: orphan

How can you use “orphan” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • orphan" G-protein coupled receptors), because every sequence is most similar to something.

  • The 26S proteasome is responsible for the bulk turnover of cytoplasmic and nuclear proteins in eukaryotic cells and also plays a key role in the regulation of cell cycle, signal transduction, transcription as well as antigen presentation [ 17 18 19 20 21 ] . Most of the known proteasomal substrates are marked and targeted to proteasome by ubiquitination [ 17 19 20 ] . Ubiquitination, however, is not an obligatory step for substrate targeting to proteasome [ 17 18 20 ] . The degradation of the ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine synthesis, involves a protein named antizyme (Az), which binds and targets ODC to 26S proteasome for degradation [ 18 ] . However, ODC has remained an "orphan" in Az-dependent proteasomal degradation.

  • But Hughes must have realized his mistake, because the next year he essentially rewrote it as Some Kind of Wonderful . The quirky and talented poor kid, played by Eric Stoltz, has a crush on the prom queen, which breaks the heart of the orphan girl (!) who has been secretly infatuated with him for years.

  • If this interpretation is correct, our results confirm those of Schmid and co-workers [ 34, 59] who have shown that a large fraction of randomly sampled coding sequences and orphan genes are rapidly evolving in the genus Drosophila . Our results are also consistent with those of Ashburner et al . [ 60] who show that genes with known mutant phenotypes in D. melanogaster are more likely to have a conserved homolog in GenBank relative to predicted genes with no known phenotype.

  • Until recently, LC-PUFA effects on gene transcription were thought primarily to be mediated by a single subfamily of orphan nuclear receptors - peroxisome proliferator activated receptors (PPARs); however, it is now becoming evident that FAs can affect many different genes either via direct interactions or indirectly through additional transcription factors including hepatic nuclear-4α (HNF-4α), nuclear factor κβ (NF-κβ), retinoid X receptor α (RXRα), sterol regulatory element binding protein-1c (SREBP-1c), and liver X receptors (LXRα and LXRβ) [ 17 ] . Indeed, the enthusiasm for uncovering the biological pathways underlying the beneficial actions of LC-PUFA has revealed a story that is increasingly more complex than originally supposed [ 23 ] , thereby making microarray technology an ideal platform to further decipher the many roles of these nutritional lipids.


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