Example sentences for: orotic

How can you use “orotic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It has been reported before that an increased excretion of orotate in sick children may not be uncommon and that a positive allopurinol load test may indicate unrecognized mitochondrial disease, making orotic acid as a potential marker of mitochondrial dysfunction [ 35 ] . A potential link between mitochondrial cytopathies and urea cycle dysfunction has also been suggested by the findings of hypocitrullinemia in patients with neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome (Mendelian Inheritance in Man database *551500) caused by a T8993G mutation in mtDNA that triggers ATPase deficiency [ 36 37 ] . It was hypothesized that the NARP mutation would cause complex V deficiency in the small intestine as well, thus reducing the availability of mitochondrial ATP required for citrulline synthesis.

  • Her urine orotic acid was mildly elevated at 81 nmoles orotic acid/mg creatinine (normal range:<60 nmoles orotic acid/mg creatinine).

  • We suspect that this proband's 3-MGC aciduria reflects a defect in mitochondrial energy metabolism and that her mild orotic aciduria may be a nonspecific marker of mitochondrial dysfunction.

  • Her special diet was discontinued prior to discharge since the results of plasma amino acids, urine organic acids, and urine orotic acid did not support the possible diagnoses of a primary urea cycle disorder or organic acidemia as the etiology of her hyperammonemia.

  • The presence of mild increase in the urinary excretion of orotic acid in this patient could also suggest mitochondrial dysfunction, convalidating this hypothesis.


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