Example sentences for: immunosuppressive

How can you use “immunosuppressive” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Cyclosporine (CsA) and tacrolimus (TAC) are the primary immunosuppressive drugs used for the prevention of acute rejection after renal transplantation.

  • Maintenance immunosuppressive medication use, in particular cyclosporine and tacrolimus, at the time of discharge after transplantation was also analyzed as a preexisting covariate.

  • In addition to the immunosuppressive toxicities, other risks are associated with the islet transplant procedure itself, including intra-abdominal hemorrhage following the transplant, and portal vein thromboses.

  • The selective suppression of Th1 cell activity is believed to be due to IL-10 inhibition of IL-12, a differentiation factor for Th1 cells [ 11 12 ] . The release of reactive oxygen and nitrogen intermediates by macrophages is also suppressed by IL-10 [ 13 14 ] . In addition, IL-10 stimulates the production of cytokine inhibitors such as IL-1 receptor antagonist [ 15 ] . In patients with rheumatoid arthritis, IL-10 is produced by synovial membrane cells and is found at high levels in the synovial fluid [ 16 17 ] . It has been shown that suppression of IL-10 production by synovial cells is associated with increased levels of IL-1 and TNF-α, suggesting that IL-10 plays a suppressive role in rheumatoid arthritis joints [ 16 ] . It was also observed that IL-10 directly stimulated proteoglycan synthesis and reversed the cartilage degradation induced by activated mononuclear cells [ 18 ] . These immunosuppressive activities indicate that IL-10 is a potential therapeutic approach for autoimmune diseases.

  • The addition of SRL to the immunosuppressive regimen of Tac resulted in decreased lymphocyte proliferation exhibiting decreased allo-immune response.


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