Example sentences for: imatinib-resistant

How can you use “imatinib-resistant” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Indeed, about three years after the recognition of imatinib resistance mutations in BCR-ABL-positive CML, new drugs are now in clinical trials that are potent inhibitors of imatinib-resistant BCR-ABL mutants [13,14].

  • Recently, new small-molecule inhibitors have been identified that retain activity against the majority of imatinib-resistant BCR-ABL mutants.

  • It is also possible that EGFR amplification itself plays a role in acquired resistance, since imatinib-resistant clones have been shown to lack resistance mutations but contain amplified copies of BCR-ABL [11,28].

  • Resistance mutations identified via in vitro screens have shown a high degree of correlation with those that develop in vivo, as shown in screens for imatinib-resistant BCR-ABL mutants [11] and PKC412-resistant FLT3 mutants [17], as well as the T790M resistance mutation to gefitinib in the context of EGFR [18].

  • Although there are many potential mechanisms for development of clinical resistance, most cases of imatinib-resistant CML are due to point mutations in the BCR-ABL kinase domain itself, including T315I [10,11].


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