Example sentences for: heptamer

How can you use “heptamer” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The initial CAC of the heptamer is highly conserved, but all remaining positions show moderate to very low levels of conservation (reviewed in [ 45]).

  • Using the ZAS-N- and ZAS-C-selected DNA sequences as input, the MEME program discovered motifs containing sequences similar to the κB or Sb transcriptional enhancer motifs as well as the conserved heptamer or nonamer elements of the RSS.

  • For example a copy of GGTTT and its complement can form a sequence GG(N 5-6 )CC, fulfilling the minimal DNA binding requirement for the ZAS proteins other than a lack of the 5' guanine [ 25 ] . Similarly, the GT-rich RSS nonamer and the palindromic RSS heptamer can serve as binding sites of KRC.

  • With respect to the heptamer (canonical sequence: CACAGTG), the CAC sequence bordering the recombination site is the most conserved segment of the sequence [ 32 ] , and mutation of these nucleotides has been found to decrease V(D)J joining in transfection assays using recombination substrates [ 40 ] . Because the sequence of the canonical RSS heptamer is palindrome, we speculate that the TGTG sequence may be sufficient for KRC/ZAS-C binding.

  • Potentially, the DNA binding domains of KRC might interact with the range of heptamer and nonamer sequences found in endogenous antigen receptor loci.


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