Words similar to degradation
Example sentences for: degradation
How can you use “degradation” in a sentence? Here are some example sentences to help you improve your vocabulary:
In F9 cells, RARγ2 plays a key role in primitive endoderm differentiation [ [ 58 59 ] ]. 48 hours after addition of T-RA degradation of this protein begins such that by 3-4 days most of the protein is depleted [ 42].
This is true of the transcription factor Cubitus interruptus (Ci): it is cleaved and its C-terminal portion is degraded [ 25 ] [ 26 ] [ 27 ] . Cleavage and degradation require phosphorylation, SCF Slmb, and proteasomal activity.
The A326S mutation of α i1 and A366S mutation of α s (cognate to the α i2 A327S used in this study) were shown to cause greatly decreased affinity for GDP [ 9 10 ] . Defective binding of GDP leads to more Gα in the empty state (no bound guanine-nucleotide), and this form of Gα is rapidly denatured in vitro , as shown for α s A366S and α i1 A326S [ 9 10 ] . Moreover, α s A366S was demonstrated to undergo rapid degradation (t 1/2 < 1 h) in stably transfected cells [ 9 ] . The same mutation in α t has also been shown to greatly decrease guanine-nucleotide binding [ 5 22 ] . Additional amino acids in the critical β6-α5 loop are important for maintaining Gα integrity [ 7 ] .
From terrorism to global disease or environmental degradation, the challenges have become transnational rather than international.
[ 20 ] ]. High-risk HPV E6 and E7 gene expression can independently immortalize various human cell types in vitro . The E6 gene interacts with p53 and an apoptotic protein BAK , followed by its degradation, which results in chromosomal instability and resistance to apoptosis [ 21 22 ] . The E7 protein interacts with pRB followed by its degradation [ 23 ] . The p53 and pRB proteins have been shown to play multiple roles in cell growth and in genomic integrity.
Loading...