Words similar to allele-specific
Example sentences for: allele-specific
How can you use “allele-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:
Illustrating that allele-specific cis -acting sequences must dictate TAS-position use, alleles differ at most TAS positions: only 3 are used by all alleles; 24 positions (†-marked) are used by more than one, but not all alleles, and 19 positions (*-marked) are used by only one allele.
Although population heterozygote advantage and allele-specific overdominance are different [ 10 ] , reports of population heterozygote advantage have frequently been interpreted as confirmations of the Doherty-Zinkernagel hypothesis of allele-specific overdominance.
Moreover, direct estimates of the allele-specific effects of heterozygosity (relative to the corresponding homozygotes), nearly absent in the infectious disease-HLA literature, are frequently found in studies of HLA genotype and chronic (mostly autoimmune) diseases [ 28 29 30 ] . We do not know the reason for this difference in approach, but suspect that some infectious disease investigators, informed by the evolutionary hypothesis of overdominance for infectious disease resistance and by animal studies, may have a special interest in detecting effects of heterozygosity per se . Many studies of HLA-autoimmune disease associations, on the other hand, seem to focus more on the effects of individual alleles and, having established these, move on to investigate the dependence of these effects on genetic modifiers, including the identity of the individual's other allele at the same locus.
P1 is an "Amplifluor™"-primer, with a 5' hairpin and loop structure with a fluorophore and quencher at the base of the hairpin arms [ 13 12 16 ] . The two allele-specific OCPs have different backbone sequences complementary either to a FAM- or TET- labeled P1 allowing discrimination of the polymorphic base.
Having established that DEK and NF-Y in nuclear extracts participate in the HLA-DQA1*0101 binding complex, we used recombinant full-length DEK (rDEK) to determine whether it alone can bind to Y-box motifs and to examine how gene- and allele-specific sequence polymorphisms alter its binding.
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