Example sentences for: acly

How can you use “acly” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In the cytoplasm, FA synthesis is controlled via Acly, acetyl CoA carboxylase (ACC), and Fasn.

  • Although ACC was not regulated at the transcriptional level, cytoplasmic citrate (generated from the Acly reaction) is an allosteric activator of ACC, so less cytoplasmic citrate would lead to less activation of ACC [ 45 ] . Transcript levels of hepatic acetyl CoA synthetase 1 AMP forming (acetate:CoA ligase AMP forming; Acas1) were consistently down regulated by LC-PUFA (-2.

  • It has previously been shown that the Acly gene in human cultured hepatic cells has a regulatory region from -61 to -49 in the 5' flanking region similar to that of Fasn, which is responsive to insulin and LC-PUFA [ 44 ] . In the present experiment, there was coordinated down regulation of both Acly (between -1.

  • The Acly reaction enhances FA synthesis by providing more acetyl CoA and NADPH substrates and enhancing ACC activity.

  • As described above, Acly expression (and possibly ACC activity) was significantly down regulated by LC-PUFAs, likely leading to less FA synthesis.


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