Example sentences for: acetylation

How can you use “acetylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Recent studies demonstrated acetylation of p53 in the C-terminal domain increased the DNA-binding capacity of the protein [ 53, 54, 55].

  • Whereas the phosphorylation of CDK9 strengthens this complex [16], the acetylation of the lysine at position 50 in Tat weakens it [17].

  • The characterization of potentially altered interactions between hypophosphorylated RARα and its cofactors will provide unique insight into how post-translational modification of nuclear hormone receptors regulates repressor release, coactivator recruitment, histone acetylation, and transcriptional activation.

  • Finally, transcription factors can alter local chromatin structure by modifying histones (typically through methylation, acetylation, and substitution of histone subunits) to permit or restrict access to the DNA.

  • For example, p53's DNA binding activity is increased by the DNA damage-induced acetylation of the C-terminal of p53 [ 16, 19], and this acetylation requires the prior phosphorylation of the N-terminal of p53 [ 16].


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