Words similar to acetylcholine
Example sentences for: acetylcholine
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All residues in the close vicinity of this ligand were confirmed experimentally as being part of the acetylcholine binding pocket [ 6 ] . While the homology between AChBP and the nAChR subunits is relatively low (22 % sequence identity, for instance, between alpha4 and AChBP), and the overall model needs to be refined, 72% of the AChBP residues in contact with HEPES are identical in the alpha4-beta2 nAChR (Figure 1), and the predicted conformation of the agonist binding pocket of nAChR is expected to be accurate.
Our staining pattern for nicotinic acetylcholine receptors as demonstrated with the α-ARD antibody resembles very closely the pattern observed originally in
Based on our models, we calculated the binding energy of acetylcholine and nicotine to the four receptor isotypes in the presence of the water molecule (Table 1- top).
Dani and his colleagues have recently shown that acetylcholinesterase inhibitors—which block the degradation of acetylcholine and hence prolong its action—used to treat Alzheimer disease also stimulate dopamine release.
This is in agreement with previous work assigning a cation-pi interaction between acetylcholine and this residue exclusively [ 9 ] . The carbonyl oxygen of acetylcholine and backbone nitrogen of Leul46 are also engaged in a hydrogen bond.