Example sentences for: γ-secretase

How can you use “γ-secretase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • ROCK1 has recently been implicated in modifying the site of substrate cleavage by APP γ-secretase [28], perhaps acting via ROCK1-dependent phosphorylation of a component of the γ-secretase enzyme complex.

  • If α-secretase stimulation is to be truly viable as a human clinical intervention, it will be essential to assess the possibility that enhanced APP ectodomain shedding might incur mechanism-based toxicity (analogous to the concerns currently surrounding γ-secretase inhibitors).

  • These investigators discovered that activation of ROCK1 may account for how nonsteroidal anti-inflammatory drugs specify the scissile bond within the APP transmembrane domain that is cleaved by presenilin/γ-secretase to generate the C-terminus of Aβ.


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