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Example sentences for: βerko

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A recent study of βERKO mice has shown that ERβ is not required for the normal prepubertal development of the mammary gland but for organization and adhesion of epithelial cells during pregnancy and hence for differentiated tissue morphology [ 23 ] . These observations indicate a possibility of complementary (sequential) roles of ERα and ERβ, since ERα appears to be required for the basic development of estrogen sensitive tissues and ERβ seems to be required for their functional maturation.
As mentioned in the Introduction, recent studies of the functional significance of ERβ in βERKO mice show that ERα is sufficient for basic differentiation of estrogen-sensitive tissue.
ERα (αERKO) and ERβ knockout (βERKO) female mice possess a normally developed reproductive tract and maintain expression of the opposite ER [ 22 ] . The αERKO female is infertile and exhibits a hypoplastic uterus that is refractory to estrogens.
In contrast, the βERKO female exhibits a hormonally responsive uterus and grossly normal ovaries, but is subfertile in terms of the frequency and size of litters.