Example sentences for: β-secretase

How can you use “β-secretase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A smaller fraction of APP molecules (approximately 20% in PC12 cells under basal conditions [5]) undergoes ectodomain shedding catalyzed by either the α-secretase (nonamyloidogenic) or β-secretase (potentially amyloiodgenic) pathway.

  • Most of this shedding is catalyzed by the α-secretase pathway, but a trace amount (<5% [49]) is catalyzed by β-secretase/β-site APP cleaving enzyme [50].

  • Therefore, one important function for α- and/or β-secretase processing of APP may be the eventual generation of AICD.

  • Cao and Sudhof [56] have recently discovered that the APP C-terminal fragment generated by α- or β-secretase is itself cleaved to release Aβ and an APP intracellular domain (AICD) that diffuses into the nucleus, possibly acting there as a transcription factor.


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