Words similar to α-galactosidase
Example sentences for: α-galactosidase
How can you use “α-galactosidase” in a sentence? Here are some example sentences to help you improve your vocabulary:
We hypothesized that the cerebral vasculopathy of Fabry disease is associated with abnormal cerebrovascular responses, and furthermore, that these would normalize with repeated intra-vascular infusion of α-galactosidase A [ 5 6 ] . We compared the functional cerebrovascular responses in Fabry disease to those in age and sex matched controls using both visual stimulation and acetazolamide challenge by [ 15O]H 2 O and positron emission tomography (PET) to measure rCBF.
Fabry disease is an X-linked disorder resulting in reduced activity of the lysosomal enzyme α-galactosidase A [ 1 2 ] . This results in the systemic accumulation of D-galatosyl conjugates, particularly globotriosylceramide (Gb3) [ 3 4 ] . Although the disorder is heterogeneous, patients suffer renal, cardiovascular and cerebrovascular complications [ 4 ] . Enzyme replacement therapy has recently shown to have an effect on resting cerebral blood flow abnormalities and on other organ systems functions [ 5 6 ] . In the cerebrovascular system there is an increased incidence of stroke together with vessel ectasia [ 7 ] . This may be related to the progressive accumulation of storage material in the cerebral vessel or possibly, may be due to an abnormality of vessel function [ 8 9 ] . The cerebrovascular complications are distributed predominantly in the posterior circulation with a progressive increase over time in the posterior distribution of small vessel disease as found on T 2 -weighted images or fluid attenuated inversion recovery (FLAIR) MR [ 7 10 11 ] . It likely that such high signal lesions on MR images represent ischemic small vessel disease, however, there are no neuropathological-radiological correlative studies confirming this assumption.
This finding suggests that the underlying abnormality is present at the luminal side of the blood-brain barrier (BBB) complex and is due to an abnormality of the cerebral vessels since it is unlikely that α-galactosidase A crosses the BBB to any appreciable extent.
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