Words similar to α-chain
Example sentences for: α-chain
How can you use “α-chain” in a sentence? Here are some example sentences to help you improve your vocabulary:
al (1996) reported that the Myelodysplasia syndrome 1(MDS1) gene spliced into exon 2 of the adjacent Ecotropic viral integration site 1 (EVI1) gene, producing a unique transcript containing an ORF that produces a GATA-binding transcriptional activator [ 30 31 ] . The human Galactose-1-phosphate uridylytransferase (GALT) gene produces an intergenic transcript by skipping its last exon and splicing into exon 2 of Interleukin-11 receptor α-chain (IL-11Rα) [ 32 ] . This produces an intergenic transcript that keeps the endogenous frame of both genes, thereby coding for a theoretical protein with domains from both proteins.
Recently, a subset of CD4 +T cells was identified that is present on 5-10% of CD4 +T cells in normal naïve mice and expresses CD25 (the α-chain of IL-2 receptor) [ 4 5 ] . Functional analysis of murine CD4 +CD25 +T cells showed that those cells, which constitutively express cytotoxic T-lymphocyte antigen (CTLA)-4 [ 6 7 8 ] , fail to proliferate or secret cytokines in response to polyclonal or antigen-specific stimulation, but inhibit the activation of conventional responsive T cells [ 1 2 3 8 9 ] . The suppressive activity of the CD4 +CD25 +T cells depends on signaling via the negative regulator of T-cell activation CTLA-4 [ 7 ] and requires a cell-cell interaction that possibly involves cell surface bound transforming growth factor (TGF)-β 1 [ 1 10 ] . It has been shown that B7/CD28 costimulation is essential for the development and homeostasis of the CD4 +CD25 +regulatory T cells [ 6 ] , which play critical roles not only in preventing autoimmunity but also in controlling tumor immunity and transplantation tolerance [ 2 11 ] .
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