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Example sentences for: zvad-fmk

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Mancini et al . reported that caspase-2 was localized at the Golgi complex and generated a unique cleavage product of golgin-160 [ 29 ] . Furthermore, these investigators proposed that the Golgi complex transduces proapoptotic signals [ 29 ] . A precedent for this hypothesis was provided by Nakagawa et al ., who reported that caspase-12 is localized to the endoplasmic reticulum and mediates an endoplasmic reticulum-specific apoptosis pathway [ 33 ] . In the present study, we have found that all Golgi autoantigens examined were cleaved in apoptosis in a caspase-dependent manner, as evidenced by studies showing that the pan-caspase inhibitor zVAD-fmk completely blocked the apoptotic fragmentation of these antigens.
Jurkat cells were treated with 1 μM STS for 4 hours after preincubation with the pan-caspase inhibitor 100 μM zVAD-fmk.
The generation of proteolytic fragments from Golgi autoantigens was completely blocked in Jurkat cells pretreated with zVAD-fmk (Fig.
AGA = anti-Golgi complex autoantibodies; H 2 O 2 = hydrogen peroxide; PARP = polyADP-ribose polymerase; PBS = phosphate-buffered saline; STS = staurosporine; zVAD-fmk = benzylocarbonyl-Val-Ala-Asp-fluromethylketone.
In some experiments, Jurkat cells were incubated for 1 hour in the presence of the pancaspase inhibitor benzylocarbonyl-Val-Ala-Asp-fluromethyl-ketone (zVAD-fmk) (ALEXIS), used at 100 μM, prior to addition of STS.