Words similar to zeiosis
Example sentences for: zeiosis
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As seen in this movie ( Additional File 3), the majority of the cells in the field of view (16 out of 24) undergo zeiosis, yet there is no ethidium uptake over the time frame examined, despite the higher concentration of MTX employed.
Although the cellular mechanisms remain poorly defined, it is now clear that zeiosis is associated with apoptotic cell death (for review [ 24 30 ] ). In static images, the morphological changes associated with apoptosis appear as membrane blebs covering the surface of the cells [ 31 32 33 ] . However, time-lapse images reveal that blebs protrude and retract in a dynamic fashion, a hallmark of zeiosis [ 22 23 ] . Dynamic membrane blebbing appears to involve a dramatic change in the cytoskeleton and may be induced by a caspase-3-mediated cleavage of ROCK-I, a Rho-activated serine/threonine kinase known to stimulate actinomycin-based contractions [ 31 32 33 ] . A similar profile can be seen in the videos of MTX-induced cell death in the presence of U73343 ( Files 2 and 3 ). The cells first lose adhesion to the coverslip, retract and roundup.
Zeiosis is a type of membrane blebbing associated with apoptosis [ 22 23 24 ] . Since U73343 protects cells from MTX-induced oncosis and causes zeiosis, we considered the possibility that the cells surviving the initial insult may ultimately die by apoptosis.
In conclusion, U73343 blocks the MTX-induced cell death cascade in BAECs and converts the normal blebbing profile seen with this toxin into zeiosis, a form of dynamic membrane blebbing commonly associated with apoptosis and characterized by bleb extension and retraction.
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